Nutrition. 2010 Jul 10. [Epub ahead of print]
Long-term intake of fish oil increases oxidative stress and decreases
lifespan in senescence-accelerated mice.
Tsuduki T, Honma T, Nakagawa K, Ikeda I, Miyazawa T.
Laboratory of Food and Biomolecular Science, Graduate School of
Agriculture, Tohoku University, Sendai, Japan.
OBJECTIVE: The effects of fish oil including omega-3 polyunsaturated
fatty acids on aging and lifespan are not well understood. In this
study, the influence of long-term ingestion of fish oil on lifespan
was examined in senescence-accelerated (SAMP8) mice. METHODS: We
investigated the effects of dietary fish oil on lifespan and on lipid
composition and oxidative stress in plasma and liver in SAMP8 mice.
Male mice were fed a fish oil diet (5% fish oil and 5% safflower oil)
or a safflower oil diet (10% safflower oil) from 12 wk of age.
RESULTS: The SAMP8 mice fed fish oil did not have a longer maximum
lifespan and had a shorter average lifespan than mice fed safflower
oil. To examine the mechanism underlying these results, the effects on
oxidative stress of long-term ingestion of fish oil were also
examined. SAMP8 mice fed fish oil for 28 wk showed strong oxidative
stress that caused hyperoxidation of membrane phospholipids and a
diminished antioxidant defense system due to a decrease in tocopherol
compared with mice fed safflower oil. CONCLUSION: These findings
suggest that intake of fish oil increases oxidative stress, decreases
cellular function, and causes organ dysfunction in SAMP8 mice, thereby
promoting aging and shortening the lifespan of the mice. Copyright ©
2010 Elsevier Inc. All rights reserved.
PMID: 20621447 [PubMed - as supplied by publisher]
Quindi abbiamo che l'olio di pesce, se non lo prendo assieme a dei tocoferoli, fa MALE (in termini di life expectancy);
Aggiungendo dei tocoferoli probabilmente il massimo che riusciamo ad ottenere è di renderlo ininfluente (sempre in termini di life expectancy).
Ma che lo prendiamo a fare quindi? Gli omega 3 funzionano solo in quanto immunosoppressori, ovvero vanno a mascherare e dare sollievo in tutta quella selva di sintomatologie legate ad un sistema immunitario iperattivo. Mascherano il problema, non lo risolvono. La soluzione è nell'evitare gli insulti al sistema immunitario, che normalmente originano da disbiosi intestinale, che normalmente origina da alimentazione scorretta. Che normalmente origina dal prestare troppo orecchio ai consigli dei dietologi. [}

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