STATO DELL'ARTE, da Skin diseases Hair physiology and its disorders
Kevin J. McElwee1, 2, , and Rodney Sinclair3
1Department of Dermatology and Skin Science, The University of British Columbia, 835 West Tenth Avenue, Vancouver, BC V5Z 4E8, Canada
2Vancouver Coastal Health Research Institute, The University of British Columbia, Vancouver, BC, Canada
3Department of Dermatology, St. Vincent's Hospital, Melbourne, Fitzroy, Australia
Available online 7 May 2008.
Drug promotion of hair growth
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Minoxidil-based treatments in multiple topical formulations
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Increased duration of anagen hair growth and increased hair follicle size
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McNeil-PPC, Inc.
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All trials complete, commercially available
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[[24] and [27]]
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Drug inhibition of androgen-mediated hair loss
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Oral finasteride inhibitor of Type II 5 alpha reductase
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Reduced action of dihydrotestosterone in androgenetic alopecia. Increased duration of anagen hair growth and increased hair follicle size
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Merck & Co., Inc.
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All trials complete, commercially available
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[[24] and [25]]
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Drug inhibition of androgen-mediated hair loss
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Blockade of androgen production or androgen receptors using antiandrogen drugs (spironolactone, cyproterone acetate)
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Reduced action of testosterone and dihydrotestosterone in androgenetic alopecia. Increased duration of anagen hair growth and increased hair follicle size
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Multiple
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Limited clinical studies complete, commercially available
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[[29] and [30]]
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Drug inhibition of androgen-mediated hair loss
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Oral dutasteride inhibitor of Type I and Type II 5 alpha reductase
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Reduced action of dihydrotestosterone in androgenetic alopecia. Increased duration of anagen hair growth and increased hair follicle size
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Glaxo Smith Kline, Inc.
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Phase III trials active
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[26]
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Drug modification of hair follicle size
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Activation of the sonic hedgehog (Shh) gene pathway using agonists
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Increased duration of anagen hair growth and increased hair follicle size
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Curis, Inc.
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Preclinical research
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[28]
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Drug modification of hair follicle size
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Ammonium trichloro(dioxoethylene-O,OŒ-)tellurate compounds
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Increased duration of anagen hair growth and increased hair follicle size
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BioMas Ltd
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Phase II clinical trials planned for 2008
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[31]
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Drug modification of hair follicle size
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Tetrapeptide aldehyde proteasome inhibitors
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Increased duration of anagen hair growth and increased hair follicle size
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Neosil, Inc.
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Phase II clinical trials planned for 2008
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ClinicalTrials.gov Identifier: NCT00418730
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Hair follicle formation
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New hair follicle induction using promoters of WNT gene activity
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Increased number of new hair follicles per unit area
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Follica, Inc.
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Phase I clinical trials planned for 2008
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[13]
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Hair follicle regeneration Hair follicle replication and/or reactivation using cell implantation Increased number of new hair follicles and/or increase size of miniaturized hair follicles Aderans Research, Inc. Pilot clinical trials complete [[23] and [32]]
Intercytex, Inc. Phase II clinical trials planned for 2008
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Phoenix Bio Co., Ltd
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Unknown
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Hair follicle redistribution Surgical transplantation of hair follicles from donor regions to alopecic scalp skin Modification of hair follicle density in alopecic scalp regions Multiple Available commercially [33]