Saccheggiando un po' la raccolta di abstract del 7° Congresso della Ricerca sui capelli:
<<Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timingof anagen entry in mouse hair follicles
AJ Kellenberger 1,2 and M Tauchi 1,2,3 1 Division of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany;
2 Institute of Anatomy II, University of Erlangen-Nuremberg,Erlangen, Germany and 3 Department of Neurology, University Hospital Erlangen, Erlangen,Germany
Mammalian target of rapamycin (mTOR) has a critical role in the regulation of cell growth andsurvival by integrating major signal inputs, such as nutrients, growth factors, energy, and stress.There is limited evidence that mTOR influences hair follicles (HFs), which undergo cycles of quiescence (telogen), growth (anagen), and regression (catagen). Activated mTOR was detected intelogen HFs and it is known that diverse molecules taking part in the mTOR signaling pathway,including Wnt, FGF-1 and Akt-related molecules, control HF proliferation. Thus, we sought toinvestigate whether mTOR, in particular mTOR complex 1 (mTORC1), regulates the hair growth cycle by using immunohistochemical, biochemical, and in vivo functional approaches. mTORactivity was quantitatively evaluated by measuring mTORC1-specific kinase activity throughout the hair cycle. The analysis of mTORC1 kinase activity showed phase-dependent changes: low in telogen, high in anagen, and late morphogenesis. The localization of activated mTOR in HFs wasassessed by immunohistochemical staining using antibodies against phosphorylated mTOR atS2448 (p-mTOR) and phosphorylated p70S6K at T389 (p-p70S6K), a downstream target of mTOR. In telogen, only scattered p-mTOR/p-p70S6K-positive cells were detected in the bulge region;however, when anagen initiation approached, the number of stained cells was increased. These results were indicative for mTOR’s role in hair growth initiation at the onset of anagen.
In vivo pharmacological analysis using the specific mTORC1 inhibitor, rapamycin, showed a delay in the hair cycle initiation, reflecting mTOR’s role in temporal regulation of anagen initiation. This study adds functional evidence that mTOR signaling is involved in the hair cycle regulation. We suggestthat mTORC1 may modulate the timing of anagen initiation in HFs.>>
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