L'inibizione dell'mTor dovrebbe essere la panacea di tutti i mali e la strada più breve all'immortalità (o quasi), ma gli aminoacidi ramificati (i BCAA, potentissimi attivatori dell'mTor) allungano la vita. Come la mettiamo?
http://www.sciencedaily.com/releases/2010/10/101005121710.htm
I nitrati (vedi salame e schifezze simili) dovrebbero far male alla salute, ma allo stesso tempo, evidenze cliniche alla mano, aiutano i nostri mitocondri e contrastano la sindrome metabolica. Come la mettiamo?
Nitrate Improves Mitochondrial Function
The spinach-eating cartoon character Popeye has much to teach us, new
research from the Swedish medical university Karolinska Institutet
shows. The muscles' cellular power plants - the mitochondria - are
boosted by nitrate, a substance found in abundance in vegetables such
as lettuce, spinach and beetroot.
For half a century, inorganic nitrate has been associated with
negative health effects, but more recently, evidence of the contrary
has mounted. In the 1990s, a research group at Karolinska Institutet
demonstrated how the body can convert nitrate to NO, a molecule
involved in many important bodily functions, such as blood pressure
regulation, the immune defence and cell metabolism.
In this new study, the same team had healthy people take nitrate
equivalent to 200-300g of spinach or lettuce for three days, after
which they were given a cycling task to perform. The researchers then
analysed samples from their thigh muscles and compared them with
similar samples from the same subjects when they had taken a placebo
instead. After nitrate ingestion, a significant improvement was seen
in the efficiency of the mitochondria, which consumed less oxygen and
produced more of the energy-rich substance ATP per consumed oxygen
molecule.
The mitochondria play a key role in cellular metabolism, says
Professor Eddie Weitzberg, who is heading the study with Professor Jon
Lundberg. Improved mitochondrial function probably has many positive
effects on the body, and could explain some of the health benefits of
vegetables.
The results, which are published in Cell Metabolism, are of sports-
physiological interest, as they show that nitrate reduces oxygen
consumption during physical exercise; however, they are also of
potential significance to diseases involving mitochondrial
dysfunction, such as diabetes and cardiovascular disease.
The group has also recently shown that nitrate reduces the blood
pressure of healthy individuals and that in laboratory animals it
counteracts components of the metabolic syndrome, a pre-stage of
diabetes. Other scientists have demonstrated protective effects of
nitrate and nitrite in animal models against heart attack and stroke.
Publication:
Filip J Larsen, Tomas A Schiffer, Sara Borniquel, Kent Sahlin, Björn
Ekblom,Jon O Lundberg, Eddie Weitzberg
Dietary inorganic nitrate improves mitochondrial efficiency in humans
Cell Metabolism, 2 February 2011
Dietary inorganic nitrate reverses features of metabolic syndrome in
endothelial nitric oxide synthase-deficient mice
Mattias Carlströma,b, Filip J. Larsena, Thomas Nyströmc, Michael
Hezela, Sara Borniquela, Eddie Weitzberga,1,2, and Jon O. Lundberga,
1,2
Published online before print September 27, 2010
aDepartment of Physiology and Pharmacology, Karolinska Institutet,
SE-171 77 Stockholm, Sweden;
bDepartment of Medical Cell Biology, Division of Integrative
Physiology, Uppsala University, SE-75123 Uppsala, Sweden; and
cDepartment of Clinical Science and Education, Division of Internal
Medicine, Unit for Diabetes Research, Karolinska Institutet,
Södersjukhuset, SE-118 83 Stockholm, Sweden
Edited* by Louis J. Ignarro, University of California Los Angeles
School of Medicine, Los Angeles, CA, and approved September 7, 2010
(received for review June 23, 2010)
#8629;1E.W. and J.O.L. contributed equally to this work.
Abstract
The metabolic syndrome is a clustering of risk factors of metabolic
origin that increase the risk for cardiovascular disease and type 2
diabetes.
A proposed central event in metabolic syndrome is a decrease in the
amount of bioavailable nitric oxide (NO) from endothelial NO synthase
(eNOS).
Recently, an alternative pathway for NO formation in mammals was
described where inorganic nitrate, a supposedly inert NO oxidation
product and unwanted dietary constituent, is serially reduced to
nitrite and then NO and other bioactive nitrogen oxides.
Here we show that several features of metabolic syndrome that develop
in eNOS-deficient mice can be reversed by dietary supplementation with
sodium nitrate, in amounts similar to those derived from eNOS under
normal conditions. In humans, this dose corresponds to a rich intake
of vegetables, the dominant dietary nitrate source. Nitrate
administration increased tissue and plasma levels of bioactive
nitrogen oxides.
Moreover, chronic nitrate treatment reduced visceral fat accumulation
and circulating levels of triglycerides and reversed the prediabetic
phenotype in these animals.
In rats, chronic nitrate treatment reduced blood pressure and this
effect was also present during NOS inhibition.
Our results show that dietary nitrate fuels a nitrate–nitrite–NO
pathway that can partly compensate for disturbances in endogenous NO
generation from eNOS.
These findings may have implications for novel nutrition-based
preventive and therapeutic strategies against cardiovascular disease
and type 2 diabetes.
doi: 10.1073/pnas.1008872107
]), può condurre a varie sostanze anche naturali e non mi pare secondario scoprire che una malattia genetica seria come l'epidermolisi bullosa possa essere curata con sulforafano, ad ogni modo lo studio vero è proprio è questo: