http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=807108
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=806852
http://jama.ama-assn.org/cgi/content/abstract/284/12/1534
http://www.ajcn.org/cgi/content/short/70/3/307
http://www.jacn.org/cgi/content/abstract/19/1/61
http://dx.doi.org/10.1016/j.jcs.2008.01.002
There is strong epidemiological evidence that whole-grain cereals protect the body against age-related diseases such as diabetes, cardiovascular diseases and some cancers. This may be due to the fibre and micronutrients in the outer layer and germ fractions of the grain acting together to combat oxidative stress, inflammation, hyperglycaemia and carcinogenesis. Oxidative stress is associated with these metabolic diseases. Whole-grain cereals are a good source of vitamin E, folates, phenolic acids, zinc, iron, selenium, copper, manganese, carotenoids, phytic acid, lignins, lignans, and alkylresorcinols, all of which have significant antioxidant potential in vitro. Phenolic acids such as ferulic acid are characteristic of cereals. They may scavenge free-radical oxygen species both in vitro and in vivo. Phenolics may also act in vivo by triggering gene induction/repression via cell signalling through transcription factors. Whole-grain cereals are also a good source of betaine, choline and sulphur amino acids that can improve antioxidant status. Betaine, which accounts for about 1% (w/w) of the bran fraction in wheat, acts as a methyl donor that may decrease hyperhomocysteinaemia, a cardiovascular risk factor, but it has been neglected. Cereals and cereal products are antioxidative in vitro, as are most fruits and vegetables. The in vitro antioxidant capacity of cereals and their constituent fractions is significantly correlated with their polyphenol content, except for maize. However, the in vitro antioxidant capacity of cereals is only an approximate reflection of their in vivo antioxidant effect due to differences in antioxidant solubility/bioavailability within the digestive tract and the metabolism/conjugation of compounds such as polyphenols. During digestion, the antioxidant capacity of cereals is increased and is likely to provide a favourable antioxidative environment for the epithelium tract, notably in the large intestine. Most of the studies performed on animals have been concerned with the antioxidant property of coloured rice, especially black rice and its anthocyanin fraction, showing a positive effect on some antioxidant biomarkers. Those very few studies that have been done on humans have shown that wheat bran and rye product supplements have no effect on antioxidant status, while a black rice pigment fraction and an avenanthramide-enriched mixture extracted from hulled oats have a positive effect. In vivo studies are therefore needed to further explore the real antioxidant potential of cereals.
(consiglio pertanto orzo mondo, avena e riso integrale nero)