Nuovo studio risolutivo capelli bianchi --
- Thread starter noel830
- Start date
Ok, Grazieee!!!Marlin ha scritto:
Chiederò sull'Antiage e ti faccio sapere.
Poniamo che i melanociti non siano morti:
http://www.ncbi.nlm.nih.gov/pubmed/26370651
There is some emerging evidence that the HF pigmentary unit may have regenerative potential, even after it has begun to produce white hair fibers.
Ciao
MA - r l i n
Chiederò sull'Antiage e ti faccio sapere.
Poniamo che i melanociti non siano morti:
http://www.ncbi.nlm.nih.gov/pubmed/26370651
There is some emerging evidence that the HF pigmentary unit may have regenerative potential, even after it has begun to produce white hair fibers.
Ciao
MA - r l i n
Marlin ha scritto:
Non vedo un INci, probabile che sia estratto acquoso, quindi o gli aggiungi alcool o lo mischi ad altra lozione per capelli.
Ciao
MA - r l i n
Volendo aggiungerlo per esempio al Tricomelan...o ai Copper Peptides Kmax....in che percentuale andrebbe aggiunto? 50% e 50%?
Non vedo un INci, probabile che sia estratto acquoso, quindi o gli aggiungi alcool o lo mischi ad altra lozione per capelli.
Ciao
MA - r l i n
Volendo aggiungerlo per esempio al Tricomelan...o ai Copper Peptides Kmax....in che percentuale andrebbe aggiunto? 50% e 50%?
F
fenderman
Visitatore
Marlin ma anche in ambito canizie dovremmo pensare ai liposomi?
Future directions
There is an increasing interest in the hair follicular route for delivery of active compounds affecting the hair. Current research activities focus on topical liposome targeting for melanins, genes, and proteins selectively to hair follicles for therapeutic and cosmetic modification of hair (Hoffman 1998). For example, topical liposome selective delivery to hair follicles has demonstrated the ability to color hair with melanin. Finally, yet another line of research in the quest of new treatments for hair loss is tissue engineering with cells of hair follicular origin with inductive properties
tratto da : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695167/
Nel senso..converrebbe acquistare il sonicatore anche a questo scopo?
Mi domando solo perché non si è puntato molto in ambito tricologico sui liposomi se questo articolo è del 2006..
Future directions
There is an increasing interest in the hair follicular route for delivery of active compounds affecting the hair. Current research activities focus on topical liposome targeting for melanins, genes, and proteins selectively to hair follicles for therapeutic and cosmetic modification of hair (Hoffman 1998). For example, topical liposome selective delivery to hair follicles has demonstrated the ability to color hair with melanin. Finally, yet another line of research in the quest of new treatments for hair loss is tissue engineering with cells of hair follicular origin with inductive properties
tratto da : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695167/
Nel senso..converrebbe acquistare il sonicatore anche a questo scopo?
Mi domando solo perché non si è puntato molto in ambito tricologico sui liposomi se questo articolo è del 2006..
Beh, non è vero che non si è puntato molto sui liposomi sono usciti un mucchio di prodotti e proprio in quegli anni le migliori farmacie galeniche hanno iniziato a fare il loro prodotto liposomiali.
Dovrebbero servire alla penetrazione degli attivi, quindi in particolare per i melanociti che stanno proprio alla base del bulbo.
Ciao
MA - r l i n
Dovrebbero servire alla penetrazione degli attivi, quindi in particolare per i melanociti che stanno proprio alla base del bulbo.
Ciao
MA - r l i n
Ok Marlin, allora gli aggiungero' quei 10ml di alcool, alla tintura
di Mucuna. Questo dovrebbe essere utile; speriamo bene, le parti su
cui sperimentare non mi mancano.
SupaDopa con l'integratore (vedi sotto), io con la Mucuna topica e
Fenderman con il Polygonum...qualcuno ce la deve fare!!!
di Mucuna. Questo dovrebbe essere utile; speriamo bene, le parti su
cui sperimentare non mi mancano.
SupaDopa con l'integratore (vedi sotto), io con la Mucuna topica e
Fenderman con il Polygonum...qualcuno ce la deve fare!!!
F
fenderman
Visitatore
Marlin ha scritto:
Beh, non è vero che non si è puntato molto sui liposomi sono usciti un mucchio di prodotti e proprio in quegli anni le migliori farmacie galeniche hanno iniziato a fare il loro prodotto liposomiali.
In ambito tricologico? Mi sono perso anni di forum e non me ne sono accorto [
]
Avevo capito che Brotzu era stato il primo a sperimentare i liposomi in ambito capelli. Sul web non ho trovato nulla a riguardo, sono stati fatti tentativi sia per l'aga che per la canizie?[]
Per quanto riguarda il Polygonum, se contribuisse a non far progredire la canizie sarebbe già un buon passo, come il mantenimento nell'aga...buttalo via []
E visto l'avanzamento copioso del processo, nel mio caso, sarebbe anche visibile come risultato. Fingers crossed
p.s. Alla S.I. ci aggiungerò anche del magnesio..mi consigli solfato? se ha senso, va bene un 5%?
Beh, non è vero che non si è puntato molto sui liposomi sono usciti un mucchio di prodotti e proprio in quegli anni le migliori farmacie galeniche hanno iniziato a fare il loro prodotto liposomiali.
In ambito tricologico? Mi sono perso anni di forum e non me ne sono accorto [
]Avevo capito che Brotzu era stato il primo a sperimentare i liposomi in ambito capelli. Sul web non ho trovato nulla a riguardo, sono stati fatti tentativi sia per l'aga che per la canizie?[
]Per quanto riguarda il Polygonum, se contribuisse a non far progredire la canizie sarebbe già un buon passo, come il mantenimento nell'aga...buttalo via [
]E visto l'avanzamento copioso del processo, nel mio caso, sarebbe anche visibile come risultato. Fingers crossed
p.s. Alla S.I. ci aggiungerò anche del magnesio..mi consigli solfato? se ha senso, va bene un 5%?
Ai tempi c'era la famosa Lipoxidil che metteva tutto in liposomi, poi hanno iniziato le farmacie poi ancora Sinere, ci hanno riempito di prodotti liposomiali nell'ultima dozzina di anni...[], forse manca giusto quello specifico contro la canizie (forse...non ci giurerei).
Il Magnesio va bene in tutte le forme, devi trovare però la percentuale che impiastricci meno, non so se al 5% fa già questo effetto, io lo uso sul viso e un po' appiccica, ma è meno del 5%.
Ciao
MA - r l i n
], forse manca giusto quello specifico contro la canizie (forse...non ci giurerei).Il Magnesio va bene in tutte le forme, devi trovare però la percentuale che impiastricci meno, non so se al 5% fa già questo effetto, io lo uso sul viso e un po' appiccica, ma è meno del 5%.
Ciao
MA - r l i n
J Invest Dermatol. 2015 Dec;135(12):3096-104. doi: 10.1038/jid.2015.332. Epub 2015 Aug 26.
Endothelial Cells Promote Pigmentation through Endothelin Receptor B Activation.
Regazzetti C1, De Donatis GM1, Ghorbel HH2, Cardot-Leccia N3, Ambrosetti D3, Bahadoran P2,4, Chignon-Sicard B5, Lacour JP2, Ballotti R1, Mahns A6, Passeron T1,2.
Author information
1C3M, INSERM U1065, team 12, Nice, France.
2Department of Dermatology, University Hospital Center of Nice, Nice, France.
3Department of Pathology, University Hospital Center of Nice, Nice, France.
4Centre de Recherche Clinique (CRC), University Hospital of Nice, Nice, France.
5Department of Plastic Surgery, University Hospital Center of Nice, Nice, France.
6Beiersdorf AG, Front End Innovation, Hamburg, Germany.
Abstract
Findings of increased vascularization in melasma lesions and hyperpigmentation in acquired bilateral telangiectatic macules suggested a link between pigmentation and vascularization. Using high-magnification digital epiluminescence dermatoscopy, laser confocal microscopy, and histological examination, we showed that benign vascular lesions of the skin have restricted but significant hyperpigmentation compared with the surrounding skin. We then studied the role of microvascular endothelial cells in regulating skin pigmentation using an in vitro co-culture model using endothelial cells and melanocytes. These experiments showed that endothelin 1 released by microvascular endothelial cells induces increased melanogenesis signaling, characterized by microphthalmia-associated transcription factor phosphorylation, and increased tyrosinase and dopachrome tautomerase levels. Immunostaining for endothelin 1 in vascular lesions confirmed the increased expression on the basal layer of the epidermis above small vessels compared with perilesional skin. Endothelin acts through the activation of endothelin receptor B and the mitogen-activated protein kinase, extracellular signal-regulated kinase (ERK)1/2, and p38, to induce melanogenesis. Finally, culturing of reconstructed skin with microvascular endothelial cells led to increased skin pigmentation that could be prevented by inhibiting EDNRB. Taken together these results demonstrated the role of underlying microvascularization in skin pigmentation, a finding that could open new fields of research for regulating physiological pigmentation and for treating pigmentation disorders such as melasma.
Endothelial Cells Promote Pigmentation through Endothelin Receptor B Activation.
Regazzetti C1, De Donatis GM1, Ghorbel HH2, Cardot-Leccia N3, Ambrosetti D3, Bahadoran P2,4, Chignon-Sicard B5, Lacour JP2, Ballotti R1, Mahns A6, Passeron T1,2.
Author information
1C3M, INSERM U1065, team 12, Nice, France.
2Department of Dermatology, University Hospital Center of Nice, Nice, France.
3Department of Pathology, University Hospital Center of Nice, Nice, France.
4Centre de Recherche Clinique (CRC), University Hospital of Nice, Nice, France.
5Department of Plastic Surgery, University Hospital Center of Nice, Nice, France.
6Beiersdorf AG, Front End Innovation, Hamburg, Germany.
Abstract
Findings of increased vascularization in melasma lesions and hyperpigmentation in acquired bilateral telangiectatic macules suggested a link between pigmentation and vascularization. Using high-magnification digital epiluminescence dermatoscopy, laser confocal microscopy, and histological examination, we showed that benign vascular lesions of the skin have restricted but significant hyperpigmentation compared with the surrounding skin. We then studied the role of microvascular endothelial cells in regulating skin pigmentation using an in vitro co-culture model using endothelial cells and melanocytes. These experiments showed that endothelin 1 released by microvascular endothelial cells induces increased melanogenesis signaling, characterized by microphthalmia-associated transcription factor phosphorylation, and increased tyrosinase and dopachrome tautomerase levels. Immunostaining for endothelin 1 in vascular lesions confirmed the increased expression on the basal layer of the epidermis above small vessels compared with perilesional skin. Endothelin acts through the activation of endothelin receptor B and the mitogen-activated protein kinase, extracellular signal-regulated kinase (ERK)1/2, and p38, to induce melanogenesis. Finally, culturing of reconstructed skin with microvascular endothelial cells led to increased skin pigmentation that could be prevented by inhibiting EDNRB. Taken together these results demonstrated the role of underlying microvascularization in skin pigmentation, a finding that could open new fields of research for regulating physiological pigmentation and for treating pigmentation disorders such as melasma.
Parecchi mesi fa, scrissi che il mio parrucchiere aveva notato che
due suoi clienti avevano avuto una certa ripigmentazione dei capelli.
Uno era un signore che si stava curando da un glaucoma, l'altro un
cardiopatico. E' possibile che nei farmaci che utilizzavano per curarsi
ci siano le proprietà che Julien ci fa notare nell'articolo allegato
due suoi clienti avevano avuto una certa ripigmentazione dei capelli.
Uno era un signore che si stava curando da un glaucoma, l'altro un
cardiopatico. E' possibile che nei farmaci che utilizzavano per curarsi
ci siano le proprietà che Julien ci fa notare nell'articolo allegato
Per quanto riguarda la cura per il glaucoma non sarebbe il primo caso. Gia molti anni fa si parlava di ripigmentazione con l'utilizzo del colliro Lumigan (Bimatoprost)..
Anche il Latisse, il famoso farmaco che allunga le ciglia contiene il bimatoprost...
Anche il Latisse, il famoso farmaco che allunga le ciglia contiene il bimatoprost...
Si diciamo che a me vengono in mente appunto prostaglandine e lipidi precursori per unire glaucoma e cardiopatia. Quindi siamo sempre dalle parti di EPA, DHA, GLA, DGLA e simili.
Per il cuore mi viene in mente che come antidoto ai FANS anti-cox si pensava appunto all'olio di pesce che rafforzava la PGI2 che è quella che viene ad essere carente con questi farmaci, quindi siamo sempre dalle parti della prostaglandine, prostanoidi e simili.
Ciao
MA - r l i n
Per il cuore mi viene in mente che come antidoto ai FANS anti-cox si pensava appunto all'olio di pesce che rafforzava la PGI2 che è quella che viene ad essere carente con questi farmaci, quindi siamo sempre dalle parti della prostaglandine, prostanoidi e simili.
Ciao
MA - r l i n
http://www.ncbi.nlm.nih.gov/pubmed/25099157
Here we first established a hair graying model in mice which recapitulates hair graying with age, just by repeatedly plucking or shaving coat hairs. Mice usually never show significant hair graying during their normal life span. Thus, the induced hair graying is not strictly due to natural aging, however, the health of repeatedly plucked or shaved mice seems to be normal and is not accompanied by an increased death rate. This suggests that the artificial stimulation of hair regeneration by plucking or shaving extends the limit of the number of possible hair cycles set by the normal life span of mice which is normally insuffi- cient to elicit the loss of self-renewing melanocyte stem cells that would result in age-related hair graying in mice. Still, after the repeated plucking, only up to 4% of all hair follicles of the mice turned gray, showing a clear difference in that most humans over 70 years of age have mostly gray or white hairs.13 Interestingly, the numbers of melanocyte stem cells were rather constant in the two different measuring methods (Fig. 1), in contrast to those reported in hematopoietic stem cells in the bone marrow,24 in which a significant age-related increase in the number of hematopoietic stem cells was observed. It was also reported that hematopoietic stem cells present in aged bone marrow lose their self-renewing activity.24 However, we did not observe an apparent reduction in the size of individual colonies derived from aged skin, indicating that the self-renewal activity of aged follicular melanocyte stem cells is rather constant. The self-renewal potential of melano- cyte stem cells during aging should be further tested since cel- lular aging is affected in several aspects including genetic variability.
Using the mouse hair graying model, we demonstrate that factors which had been shown to sustain ectopic melanocyte stem cells in the interfollicular skin of mice, namely Kitl, HGF and ET3, are all effective in preventing the plucking- or shav- ing-induced hair graying. Although Kitl promotes the differenti- ation of melanocyte stem cells in the hair follicle, these melanocyte stem cells are maintained or survive in the absence of Kit signaling, as indicated previously.17,22,27 Recent analysis revealed that Wnt signaling is a possible self- renewal promoting cue for adult follicular melanocytes.28 If that Kit signaling does not affect the self-renewal of follicular melanocyte stem cells, mechanisms underlying the life-time protective effect of Kitl against hair graying might be more complicated, since the loss or lack of the self-renewal capac- ity of melanocyte stem cells is a theoretical cause of the hair graying. Since melanocytes were maintained continuously in the interfollicular skin of hk14-Kitl transgenic mice,17 Kit sig- naling is thought to enable the maintenance of the melanocyte stem cell system in interfollicular skin, otherwise melanocytes would be eliminated from the region shortly after birth. It might be possible that Kit signaling promotes the asymmetric division of melanocyte stem cells into differentiated precursor and stem cells which may at least maintain the melanocyte stem cell population. Alternatively, Kit signaling may induce the de-differentiation of melanocyte stem cells from their descendant melanoblasts. It should be noted that if this is the case, the maintenance or survival of melanocyte stem cells should be controlled by other factors.28 The protective effect of HGF and ET3 may also be explained in the same manner and it should be noted that ET3 was recently suggested as a factor involved in the stimulated self-renewal of follicular mela- nocytes.28 It is also possible that Kitl promotes the self- renewal of melanocyte stem cells in association with other factors, such as ET3, and in circumstances where Kitl is elimi- nated from the environment, available ET3 signaling solely and effectively maintains their self renewal.22 Whatever the molecular details are, the continuous expression of one or more of these factors may well stimulate the self-renewal of melanocyte stem cells revealed as a phenotype resistant to hair graying. It should be noted that the constitutive activation of Wnt signaling causes exhaustive proliferation and succes- sive differentiation of melanocyte stem cells revealed as early hair graying.28 however, we never observed this kind of exhaustive hair graying in any of the Kitl, ET3 and HGF trans- genic mice.
Here we first established a hair graying model in mice which recapitulates hair graying with age, just by repeatedly plucking or shaving coat hairs. Mice usually never show significant hair graying during their normal life span. Thus, the induced hair graying is not strictly due to natural aging, however, the health of repeatedly plucked or shaved mice seems to be normal and is not accompanied by an increased death rate. This suggests that the artificial stimulation of hair regeneration by plucking or shaving extends the limit of the number of possible hair cycles set by the normal life span of mice which is normally insuffi- cient to elicit the loss of self-renewing melanocyte stem cells that would result in age-related hair graying in mice. Still, after the repeated plucking, only up to 4% of all hair follicles of the mice turned gray, showing a clear difference in that most humans over 70 years of age have mostly gray or white hairs.13 Interestingly, the numbers of melanocyte stem cells were rather constant in the two different measuring methods (Fig. 1), in contrast to those reported in hematopoietic stem cells in the bone marrow,24 in which a significant age-related increase in the number of hematopoietic stem cells was observed. It was also reported that hematopoietic stem cells present in aged bone marrow lose their self-renewing activity.24 However, we did not observe an apparent reduction in the size of individual colonies derived from aged skin, indicating that the self-renewal activity of aged follicular melanocyte stem cells is rather constant. The self-renewal potential of melano- cyte stem cells during aging should be further tested since cel- lular aging is affected in several aspects including genetic variability.
Using the mouse hair graying model, we demonstrate that factors which had been shown to sustain ectopic melanocyte stem cells in the interfollicular skin of mice, namely Kitl, HGF and ET3, are all effective in preventing the plucking- or shav- ing-induced hair graying. Although Kitl promotes the differenti- ation of melanocyte stem cells in the hair follicle, these melanocyte stem cells are maintained or survive in the absence of Kit signaling, as indicated previously.17,22,27 Recent analysis revealed that Wnt signaling is a possible self- renewal promoting cue for adult follicular melanocytes.28 If that Kit signaling does not affect the self-renewal of follicular melanocyte stem cells, mechanisms underlying the life-time protective effect of Kitl against hair graying might be more complicated, since the loss or lack of the self-renewal capac- ity of melanocyte stem cells is a theoretical cause of the hair graying. Since melanocytes were maintained continuously in the interfollicular skin of hk14-Kitl transgenic mice,17 Kit sig- naling is thought to enable the maintenance of the melanocyte stem cell system in interfollicular skin, otherwise melanocytes would be eliminated from the region shortly after birth. It might be possible that Kit signaling promotes the asymmetric division of melanocyte stem cells into differentiated precursor and stem cells which may at least maintain the melanocyte stem cell population. Alternatively, Kit signaling may induce the de-differentiation of melanocyte stem cells from their descendant melanoblasts. It should be noted that if this is the case, the maintenance or survival of melanocyte stem cells should be controlled by other factors.28 The protective effect of HGF and ET3 may also be explained in the same manner and it should be noted that ET3 was recently suggested as a factor involved in the stimulated self-renewal of follicular mela- nocytes.28 It is also possible that Kitl promotes the self- renewal of melanocyte stem cells in association with other factors, such as ET3, and in circumstances where Kitl is elimi- nated from the environment, available ET3 signaling solely and effectively maintains their self renewal.22 Whatever the molecular details are, the continuous expression of one or more of these factors may well stimulate the self-renewal of melanocyte stem cells revealed as a phenotype resistant to hair graying. It should be noted that the constitutive activation of Wnt signaling causes exhaustive proliferation and succes- sive differentiation of melanocyte stem cells revealed as early hair graying.28 however, we never observed this kind of exhaustive hair graying in any of the Kitl, ET3 and HGF trans- genic mice.
E' più chiaro l'abstract:
The repeated hair plucking or shaving led to hair graying without any genetic lesion. Kitl is a more effective factor for prevention of hair graying than HGF or ET3. Our simple model of hair graying may provide a basic tool for screening the molecules or reagents preventing the progression of hair graying.
Bisognerebbe puntare quindi su Kitl:
https://en.wikipedia.org/wiki/Stem_cell_factor
...più facile a dirsi che a farsi.
Ciao
MA - r l i n
The repeated hair plucking or shaving led to hair graying without any genetic lesion. Kitl is a more effective factor for prevention of hair graying than HGF or ET3. Our simple model of hair graying may provide a basic tool for screening the molecules or reagents preventing the progression of hair graying.
Bisognerebbe puntare quindi su Kitl:
https://en.wikipedia.org/wiki/Stem_cell_factor
...più facile a dirsi che a farsi.
Ciao
MA - r l i n
Mi è arrivata la tintura di Mucuna:
http://www.ebay.it/itm/Organic-Mucuna-Puriens-Kapickachhu-Non-Alcoholic-Tincture-100ml-FREE-UK-Post-/252001843362?hash=item3aac7af8a2:g:XHIAAOSwoudW5OT8
Scusa Marlin, mi consigliavi di aggiungerci 10ml di alcool, al fine
di farla penetrare meglio; a scanso di equivoci intendevi alcool
classico a 95°?
Grazie
http://www.ebay.it/itm/Organic-Mucuna-Puriens-Kapickachhu-Non-Alcoholic-Tincture-100ml-FREE-UK-Post-/252001843362?hash=item3aac7af8a2:g:XHIAAOSwoudW5OT8
Scusa Marlin, mi consigliavi di aggiungerci 10ml di alcool, al fine
di farla penetrare meglio; a scanso di equivoci intendevi alcool
classico a 95°?
Grazie