questo è quello che ho letto in un forum straniero:
There are two types of PGD2 receptors, DP1 and DP2 (DP2 is also known as 'GPR44' and 'CRTH2'). Laropiprant (Merck's drug) selectively blocks the PD1 receptor - Cotsarelis showed that the PD2 receptor (and not PD1) is involved in hair growth downregulation. BTW, niacin produces flushing via the PD1 receptor - the PD2 receptor is not involved in the flushing at all.
Setipiprant by Actelion blocks the right PGD2 receptor implicated in MPB (PD2). Right now, setipiprant is in phase 2/3 testing.
e questo quello che è scritto sul setipiprant http://www1.actelion.com/en/scientists/development-pipeline/phase-2/setipiprant.page
Setipiprant
About Setipiprant
Actelion's CRTH2 receptor antagonist, setipiprant, blocks the effects of prostaglandin D2 (PGD2) on inflammation and, as a consequence, the amplification and maintenance of allergic reactions. It targets allergic inflammation at the beginning of the cascade, with potential to be used as controller therapy in both asthma and/or allergic rhinitis, as well as in multiple potential indications that are based on allergic inflammation.
Per quanto riguarda i semi di cumino nero, che siano compresse o olio, ciò che interesserebbe è il thymoquinone (contenuto in entrambi) che, sembra in grado di inibire la sintesi della prostaglandina d2, ma anche in misura lieve, quella della pge2
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