Ottimo Julien, comunque credo che il succo finale sia in queste frasi conclusive:
We found nosignificant evidence for interaction between
the AR locus and the autosomes for either the genome-wide
or the fine-mapping data sets (Figure 4). This might suggest
that the AGA susceptibility genes in autosomal regions
showing evidence for linkage confer their risk through
pathways other than the classical androgen pathway.
However,the power to detect interaction is limited because only
54–56 families were included in the analysis (based on their
NPL scores at the AR locus), and interaction cannot be ruled
out with the current data set. Regions on several chromosomes
show DNPLs between 1 and 2, compatible with effects
that might only be detectable in larger family samples.
The identification of 14 regions with nominal evidence
of linkage reflects and supports the opinion that AGA is
caused by multiple genes. The data provide strong evidence
for the existence of an AGA susceptibility locus on
3q26. The 11.5 Mb core region with NPL scores greater
than 3 (flanking STR markers D3S1763 and D3S3730) bears
34 reference sequence genes (University of California,
Santa Cruz genome browser, build 36) that will be the target
of future association-based studies. Among the transcripts
are no genes known to be involved in hair biology,
and the best candidates might be genes which have been
implicated in AGA-associated diseases. The growth hormone
secretagogue receptor gene (GHSR), for example,
has been previously associated with obesity.35 Another interesting
candidate is TERC, which encodes the telomerase
RNA component. Mutations in TERC and the knockout of
the mouse homolog are well known to result in various
aging phenotypes.36–38 Because AGA is an age-correlated
trait, variability in genes modulating the process of aging
might have an impact on AGA susceptibility.
In contrast to the AR gene located on the X chromosome,
27,28 the autosomal location of the AGA susceptibility
loci of the present study might explain the resemblance
of fathers and sons with respect to the development
of AGA.
Viene confmato che l'AGA è multifattoriale e non solo legata agli androgeni (o meglio al recettore AR).
Interessante l'ulteriore riscontro sul TERT (proprio oggi allestisco nuova lozione con astragalo[
] ossia l'AGA potrebbe essere quel precoce invecchiamento localizzato che colpisce lo scalpo (invecchiamento che poi sarebbe naturale quando anche il resto del corpo segue la stessa strada).
Comunque anch'io rileggerò tutto con più calma.
Ciao
MA - r l i n
