Non ho letto tutte le pagine di discussione quindi non so se quello che scrivo è già stato tutto detto, però io farei questa prova:
Innanzitutto è a tutti voi noto che:
Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia.
Garza LA, Liu Y, Yang Z, Alagesan B, Lawson JA, Norberg SM, Loy DE, Zhao T, Blatt HB, Stanton DC, Carrasco L, Ahluwalia G, Fischer SM, FitzGerald GA, Cotsarelis G.
Source
Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Abstract
Testosterone is necessary for the development of male pattern baldness, known as androgenetic alopecia (AGA); yet, the mechanisms for decreased hair growth in this disorder are unclear. We show that prostaglandin D(2) synthase (PTGDS) is elevated at the mRNA and protein levels in bald scalp compared to haired scalp of men with AGA. The product of PTGDS enzyme activity, prostaglandin D(2) (PGD(2)), is similarly elevated in bald scalp. During normal follicle cycling in mice, Ptgds and PGD(2) levels increase immediately preceding the regression phase, suggesting an inhibitory effect on hair growth. We show that PGD(2) inhibits hair growth in explanted human hair follicles and when applied topically to mice. Hair growth inhibition requires the PGD(2) receptor G protein (heterotrimeric guanine nucleotide)-coupled receptor 44 (GPR44), but not the PGD(2) receptor 1 (PTGDR). Furthermore, we find that a transgenic mouse, K14-Ptgs2, which targets prostaglandin-endoperoxide synthase 2 expression to the skin, demonstrates elevated levels of PGD(2) in the skin and develops alopecia, follicular miniaturization, and sebaceous gland hyperplasia, which are all hallmarks of human AGA. These results define PGD(2) as an inhibitor of hair growth in AGA and suggest the PGD(2)-GPR44 pathway as a potential target for treatment.
Questo mi fa pensare che a questo punto il DIRETTO responsabile della calvizie sia il PGD2 e non il DHT.
Ma allora perchè la finasteride fa ricrescere i capelli, e come mai se uno viene castrato o è reductase-deficiente allora non li perde? Che legame c'è tra PGD2 e DHT?
Rat prostaglandin D2 synthetase: its tissue distribution, changes during maturation, and regulation in the testis and epididymis.
Sorrentino C, Silvestrini B, Braghiroli L, Chung SS, Giacomelli S, Leone MG, Xie Y, Sui Y, Mo M, Cheng CY.
Source
The Population Council, New York, New York 10021, USA.
Abstract
The changes in glutathione-independent prostaglandin D2 synthetase (PGD-S) during maturation in the rat were determined in selected organs by an RIA using PGD-S purified from rat cerebrospinal fluid and a monospecific anti-rat PGD-S polyclonal antibody. In a survey of its tissue distribution in various organ extracts and biological fluids, it was found that the concentration of PGD-S was highest in the epididymis-about 6- and 80-fold greater than that in the brain and testis, respectively. During maturation, PGD-S concentration increased steadily in the testis and epididymis; this is in contrast to the pattern of changes in the brain and liver, which showed a general trend of decline. Reverse transcription-polymerase chain reaction and Southern blotting were used to demonstrate the presence of PGD-S mRNA transcript in the testis and in Sertoli and germ cells. In the epididymis, the steady-state PGD-S mRNA level was highest in the caput, followed by the cauda and corpus. Orchiectomy induced a drastic reduction of PGD-S concentration in all three epididymal compartments. Administration of dihydrotestosterone (DHT) failed to restore the reduced epididymal PGD-S level except in the caput epididymis, where 4 days after DHT treatment the level of PGD-S was restored to about 50% of the pre-orchiectomized level; this suggests that the epididymal PGD-S level is not entirely regulated by androgen and that another yet to be identified testicular factor(s) is likely to be involved in its regulation. Germ cell-conditioned medium was also shown to stimulate PGD-S expression in the Sertoli cell. These results illustrate that PGD-S is an important molecule in testicular and epididymal function and that it is likely involved in spermatogenesis and sperm maturation.
Un legame con il DHT c'è anche se non chiarissimo.
These data suggest that L-PGDS expression in mouse epididymis gradually declined in parallel to the declining concentration of endogenous androgen after castration and increased with the treatment of exogenous testosterone, indicating that L-PGDS expression in mouse epididymis was modulated by androgen levels. However, differential expression in different areas of the epididymis may also be influenced by factors derived from the testis.
Con gli androgeni in generale sembra esserci.
Quindi a mio avviso il PGD2 è il fattore DIRETTO principale dell'aga (ma non l'unico probabilmente) che miniaturizza i capelli e gli ANDROGENI i suoi REGOLATORI.
Soluzione? Bloccare PGD2 o il suo recettore dove si attacca.
Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction.
Charlesworth EN, Kagey-Sobotka A, Norman PS, Lichtenstein LM.
Source
Department of Medicine, Johns Hopkins University School of Medicine, Good Samaritan Hospital, Baltimore, Md 21239.
Abstract
A new H1 antihistamine, cetirizine, was studied to determine its effects on mediators and cellular infiltration during the cutaneous late-phase response (LPR). Ten ragweed-allergic subjects, who had previously demonstrated a cutaneous LPR, were examined in a double-blind, crossover study. Either cetirizine, 20 mg, or placebo was administered orally once daily for 2 days before and the morning of placement of a skin chamber overlying an unroofed heat/suction-induced blister to which was added antigen or buffer. Skin test erythema was significantly reduced by cetirizine at 15 minutes, 2 hours, and 4 hours by 56%, 40%, and 39%, respectively (all, p less than or equal to 0.01), but by 6 and at 8 hours, the cutaneous erythema was not significantly lessened. Histamine release was not altered by cetirizine treatment, but prostaglandin D2 (PGD2) production, which peaked at 3 to 5 hours, was clearly reduced by cetirizine treatment, being lower at all time points during the reaction; this was significant by analysis of variance (p less than or equal to 0.04). The inhibition was most marked during the fifth hour of the reaction when there was a 50% suppression of the PGD2 level by cetirizine (0.193 ng/ml to 0.075 ng/ml [p less than or equal to 0.03]). The most dramatic effect of cetirizine was attenuation of the inflammatory cell migration into the chamber. Eosinophil infiltration was decreased by about 75% during hours 6, 7, and 8 (p less than or equal to 0.04), whereas the number of neutrophils was reduced by the same magnitude at the same times (p less than or equal to 0.04).(ABSTRACT TRUNCATED AT 250 WORDS)
La cetirizina diminuirebbe in maniera significativa la PGD2 (non so però in che maniera precisa).
Our findings point to an anti-inflammatory action of cetirizine via PGE2 release and histamine H2 interactions. Cetirizine did not directly modify IL-1 generation by resting monocytes but the IL-1 production observed after LPS stimulation could promote the mechanisms by which PGE2 is released.
Qui dice che la cetirizina aumenta anche la PGE2 (positiva per i capelli). Per il poco che so l'aumento della PGD2 diminuisce la PGE2.
Infatti in diversi forum la stanno testando ORALMENTE. Cetirizina si trova nei farmaci Cerchio,Zyrtec etc. è un antistaminico.
Effetti collaterali
Nessun effetto particolare. Però per il nostro obiettivo andrebbe preso nel lungo termine e quindi non sappiamo di preciso che effetti può avere.
L'unico tester di questo farmaco nel lungo termine è l'utente ETERNAUTA del forum spagnolo che lo ha utilizzato per 6 ANNI con effetti molti positivi su se stesso (anche se utilizzava già di base fina e minox) e su altre persone che lui conosce. Ha però sottolineato che è un aiuto in più secondo lui soprattutto riguardo la dose classica di 10 mg. Preferisce prendere diverse medicine a dosi minori evitanto i sides piuttosto che utilizzarne una a dosi massiccie.
Altre testimonianze:
http://www.hairlosstalk.com/interact/viewtopic.php?f=23&p=682710
CarlosSL
Post subject: Re: A recently discovered new factor in AA, the cure is near
Posted: Fri May 11, 2012 3:04 am
Newbie
Joined: Wed Apr 18, 2012 6:39 am
Posts: 7
Hi all, (Sorry for my English)
I come from a Spanish forum, where we have 1 month testing with cetirizine. Most of us have noticed good results, less hair fall and decreased fat and itching.
TESTIMONIALS:
robertto1 wrote:
I did not want to be presumptuous and on day 2 ... but I must admit that this is better than the Fairy lol.
I run my fingers over his forehead (which at the end of the day was always oily skin), and now is that there is no trace male!
albertmag wrote:
if not psychological or but I seem to notice an improvement in hair ... 16 days ago and I take cetirizine but I have to clarify that I get minoxidil (2 years ago) and irregularly (10 days ago) I take chia oil (omega 3).
peladono wrote:
I took 11 days, must be early to assess results, which note was less grease on his forehead, and especially the most prominent by far is that: at night lately I grabbed a whole body itch Unbearable and since taking I was magically cetirizine
albertmag wrote:
I took 17 days and cut the grease and almost instantly noticed a slight improvement.
robertto1 wrote:
I will be at least until late June. At the moment the fat, I have observed from day 2 that we nipped in the bud ...
pelonovo wrote:
I took 11 days, I noticed that if the hair has fallen to me are on hand to give me Minox ...
I will continue commenting and I,,, I think this product in synergy with the other can give me a little better result ....
Lanjaron wrote:
Another one that adds to the evidence of cetirizine ... I bought 2 boxes of 20 tablets, with the last night and took 3 shots (tonight will be the fourth)
1: Miracle antrigrasa as discussed (from the second shot), it is true that I have been using treatments for excess fat in the face but .. What the hell! if I take one year using these treatments and has hardly changed. So put it down to cetirizine, but not exactly understand the relationship seborrhea leather / face - anti allergen.
2: The Fall ... Well, last night I used minoxidil and it is true that I saw only 2 hairs, but it gave me for noticing, because the truth is that I never fixed, you may always take me out 2/3 hairs. (Also, 3 days of making do not think that is meaningful to the fall, wait at least 20 days)
Artemia wrote:
5 days with Alernix:
- Low significant oiliness on the face.
- Low interest in hair loss.
- I sleep like a baby ..
alexin wrote:
8 days with cetirizine. What is strict hair fall that I can see in my hands, hair dryer and others is very true that it falls less, just nothing. As for fat, of course in the face it shows a lot, the front by example just shows the usual fat, right. On the scalp it is harder to see but I also think there is less sebum. As for side effects only, I have noticed that I sleep better, which is very positive.
Forum: http://foro.recuperarelpelo.com/viewtopic.php?t=39976
Io l'ho provata ieri sera una pastiglia e stamani il sebo è minore del solito (non che ne soffrissi). Sembra quasi scomparso del tutto.
A voi la scelta o meno di fare un test.
Ciao a tutti [
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