Provate ad applicarlo sulla cute bagnata magari è un problema di assorbimento.
Cmq l'aspirina topica era stata scartata? Inibisce il pgd2 ma anche il pge2 se non sbaglio. Mi era sembrato di aver letto in qualche studio che non era di utilità per i capelli.
Invece potrebbe interessarvi, soprattutto a Marlin cultore dei naturali questa sostanza derivata da una radice di una pianta orientale
http://www.ncbi.nlm.nih.gov/pubmed/22154852
Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells.
Lu Y, Suh SJ, Li X, Hwang SL, Li Y, Hwangbo K, Park SJ, Murakami M, Lee SH, Jahng Y, Son JK, Kim CH, Chang HW.
Source
College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
Abstract
In this study, we examined the effects of citreorosein (CIT), an anthraquinone component of Polygoni cuspidati radix (P. cuspidati, Polygonaceae), on cyclooxygenase (COX)-2 dependent prostaglandin (PG)D2 generation in mast cells, central effector cells of allergy and other inflammatory diseases. CIT strongly inhibited COX-2-dependent PGD2 generation in a concentration-dependent manner in mouse bone marrow-derived mast cells (BMMCs) stimulated with stem cell factor (SCF)/IL-10/LPS. In an effort to identify the mechanisms underlying the inhibition of COX-2-dependent PGD2 generation by CIT, we examined the effects of this compound on MAP kinases, Akt and NF-#954;B signaling pathways, which are essential for COX-2 induction. CIT inhibited nuclear translocation of the nuclear factor (NF)-#954;B p65 subunit and its cognate DNA-binding activity, which correlated with its inhibitory effects on the phosphorylation of Akt and IKK and subsequent phosphorylation and degradation of I#954;B. Furthermore, CIT significantly attenuated the DNA binding of activator protein (AP)-1 that regulates COX-2 expression through the reduction of the phosphorylation of c-Jun. Moreover, inhibition of PGD2 generation by CIT was accompanied by a decrease in phosphorylation of cytosolic phospholipase A2#945;. Taken together, the present study suggests that CIT represents a potential therapeutic approach for the treatment of inflammatory diseases.
Ho provato a cercarla ma non ho trovato molto, probabilmente è poco conosciuta.