Interessante, anche negli anziani non si perde la facoltà di generare nuovi capelli, ma con l'aga, sia giovanile che quella data dall'età, si allunga sempre di più il telogen e si accorcia l'anagen.
Abstract. Androgenetic alopecia (AGA) is the most common type of hair loss and features progressive miniaturization of hair follicles. Generally, the occurrence of AGA has long been thought to be driven by genetic and androgen predisposition. However, increasingly, data proposed ageing and AGA...
karger.com
> As a central hallmark of ageing, senescence is a cell fate that occurs in response to damage such as telomere damage, DNA damage, and mitochondrial dysfunction in ageing and involves growth arrest, resistance to apoptosis, and secretion of a host of proinflammatory factors [14]. Interestingly, the capacity of hair follicles to regenerate was not lost (except in cases of follicle destruction) in AGA, neither does the follicle cycling. Instead, the regenerated hair cycles are compromised by extended telogen and shortened anagen phases [10]. In fact the same feature occurs not only in AGA, but also in the hair loss caused by premature ageing, such as senescent alopecia and Werner syndrome and Hutchinson–Gilford progeria [15-16]. All above data suggested a mechanism of AGA related to cellular senescence. The aim of this review is to provide dermatologists an overview of the biological links between ageing and AGA, specifically focusing on cellular senescence, and discuss the therapeutic potential of targeting cellular senescence in AGA.