Molto interessante, ne hanno parlato sere fa su un noto programma italiano della Rai-3 (me lo ha riferito mia madre). La Dr.Christiano sembra molto ottimista anche nell'uso degli Jak inibitors nell'aga: Dr. Cristiano has shown it can also work on healthy hair growth and hair in rest phase and hopes it can work on androgenic alopecia because of the way it inhibits enzymes in the hair.
Nei topi ha dato ottimi risultati...
Qui un soggetto trattato per l'Areata a soli 2 mesi d'uso col Tofacitinib...
Dr. Christiano and colleagues released the documentation of their latest research “Pharmacologic inhibition of JAK-STAT signaling promotes hair growth.” This time they were testing topical formulations of the JAK inhibiting drugs, tofacitinib and ruxolitinib, as a treatment for adrogenic alopecia or “common” hair loss.
It remains to be seen if JAK inhibitors can reawaken hair follicles that have been suspended in a resting state because of androgenetic alopecia (which causes male and female pattern baldness) or other forms of hair loss. So far, all the experiments have been conducted in normal mice and human follicles. Experiments to address hair follicles affected by hair loss disorders are under way.” The wording of that paragraph leads me to believe that Dr. Chrisiano and colleagues have begun pilot studies testing JAK inhibitors in humans with androgenic alopecia, which is of course, a good thing.
- JAK inhibitors stimulate hair follicles out of the resting phase into the growing phase. They also show the ability to elongate the growing phase.
- JAK inhibitors activate the Wnt and Shh signaling pathway.
- JAK inhibitors cause the activation of hair follicle progentior (stem) cells.
- Tofacitinib (a JAK inhibitor) promotes inductivity of dermal papillae cells.
- Tofacitinib promotes hair growth by positively affecting genes within pathways that are crucial to hair growth. For example: TGFB pathway genes, BMP pathway genes, LEF1, and NOTCH pathway genes.
http://www.folliclethought.com/?p=752
Ps: la Pfizer produce il Tofacitinib in tavolette da 5 mg col nome di
Xeljanz ma in lozione non ho trovato nulla.
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