Non per screditare Galenico ma l'ho contattato chiedendo se potesse essere fattibile una preparazione come quella riportata nello studio da me postato e lui mi ha semplicemente informato che la finasteride come principio attivo sarà disponibile solo da settembre.
Io ho chiesto alla farmacia Legnani di Milano e loro sembra che sviluppino topici a base di finasteride già da un po',infatti parlando con il loro laboratorio erano sicuramente ferrati sull'argomento.
Anche basilio già da qualche mese si sta facendo preparare in una farmacia del Veneto un gel a base di finasteride...e non penso che queste siano le uniche 2 farmacie in Italia che abbiano a disposizione il principio attivo.
Non capisco perchè Galenico debba aspettare fino a settembre.
Come già dicevo, ho chiesto alla farmacia Legnani la possibilità di preparare il topico in gel con procedura identica a quella dello studio( la inserisco nuovamente così che si capisca a ciò cui mi riferisco).In caso di risposta affermativa da parte della farmacia se magari qualche utente del forum può essere interessato si potrebbe testare la cosa.
Io al momento inizierò ad utilizzare la lozione che già sono in grado di preparare con finasteride all 1%.
Ecco qui la metodologia di preparazione:
Method of finasteride gel preparation
Since the water solubility of Finesteride gel is very low, thus, at the beginning of work, solubility had to be increased. For this reason, solvent-aid was used. The solvents-aid is water mixable organic solvents, in which by decreasing solubility, and with surface tension of water, will cause increase water solubility of non-polar materials. An adequate amount of ethanol to increase solubility was determined by several examinations and by setting the drug solubility in different percentages of water-ethanol. After setting and preparing the suitable solvent to solve finasteride, several examinations to select the best polymer were done by different materials. For this reason, first the selected polymer was poured on a glass surface, containing an adequate drug solving system, and was maintained in lab temperature for 24 hours. Then, the receiving system was mixed by an electric mixer by velocity of 600 cycles per minute, until it was completely pure. The results showed that 40% water and 60% ethanol are the best solvent system, and hydroxyl propyl methyl cellulose (HPMC) is the best polymer. Preparation of this drug did not need a preservative. Physical stability of the drug as a viewpoint of deposition or opacity in 4°C in refrigerator was evaluated. Since the time frame between drug production and consumption was about one week, there was no need for chemical assessment. In addition, the placebo gel without drug was prepared by the same system. Because, finasteride 1% has the most dermal absorption, therefore, in this study finasteride gel 1% was prepared and used.
Pietro
