http://link.springer.com/article/10.1007%2FBF02005756?LI=true
L Michel, C De Vos, JP Rihoux, L Dubertret
Inhibitory effect of cetirizine on allergen-induced histamine and PGD2release and on eosinophil recruitment in allergic patients
J A LLERGY CLIN I MMUNOL, 2 (1987), p. 82
Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction
E.N. Charlesworth, MD (COL, USAF, MC), A. Kagey-Sobotka, PhD, P.S. Norman, MD, Lawrence M. Lichtenstein, MD, PhD#8727;
Abstract
A new H1 antihistamine, cetirizine, was studied to determine its effects on mediators and cellular infiltration during the cutaneous late-phase response (LPR). Ten ragweed-allergic subjects, who had previously demonstrated a cutaneous LPR, were examined in a double-blind, crossover study. Either cetirizine, 20 mg, or placebo was administered orally once daily for 2 days before and the morning of placement of a skin chamber overlying an unroofed heat/suction-induced blister to which was added antigen or buffer. Skin test erythema was significantly reduced by cetirizine at 15 minutes, 2 hours, and 4 hours by 56%, 40%, and 39%, respectively (all, p #8804; 0.01), but by 6 and at 8 hours, the cutaneous erythema was not significantly lessened. Histamine release was not altered by cetirizine treatment, but prostaglandin D2 (PGD2) production, which peaked at 3 to 5 hours, was clearly reduced by cetirizine treatment, being lower at all time points during the reaction; this was significant by analysis of variance (p #8804; 0.04). The inhibition was most marked during the fifth hour of the reaction when there was a 50% suppression of the PGD2 level by cetirizine (0.193 ng/ml to 0.075 ng/ml [p #8804; 0.03]). The most dramatic effect of cetirizine was attenuation of the inflammatory cell migration into the chamber. Eosinophil infiltration was decreased by about 75% during hours 6, 7, and 8 (p < 0.04), whereas the number of neutrophils was reduced by the same magnitude at the same times (p #8804; 0.04). Basophils appeared to enter the chamber together with the eosinophils and were decreased by 64% during hours 6 through 8, but not significantly due to small numbers. We conclude that cetirizine influences the pathogenesis of the LPR by causing a significant reduction in both the inflammatory cell infiltrate and PGD2 production. These effects apparently are not related to its anti-H1 activity.
molto interessante. La cetirizina sembra da una parte stimolare la produzione di PGE2 e dall'altra bloccare la chemiotassi e l'attivazione dei leucociti e la degranulazione e il conseguente rilascio di prostaglandine infiammatorie. I risultati dalle foto di Jacksone sembrano esserci, pur non clamorosi ma è anche breve il tempo di applicazione. Chissà tra 40 gg... Jackson come l'assumi, in compresse o sotto forma di lozione topica?
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