Julien, doppio parere:
http://www.servizitelevideo.rai.it/televideo/pub/pagina.jsp?p=163&s=0&r=Nazionale&idmenumain=7&pagetocall=pagina.jsp
http://www.northwestern.edu/newscenter/stories/2015/04/telomere-changes-predict-cancer.html
e pure:
http://www.anti-agingfirewalls.com/2015/04/08/30-major-factors-that-control-sirt1-expression-sirt1-activity-and-sit1-mediated-aging-part-3-of-the-series-nad-an-emerging-framework-for-health-and-life-extension/
....The accumulation of excess nicotinamide in cells is probably a major cause of aging. Whereas we typically associate “NAD deficiency” with aging, “Nam excess” may have a similar effect. To no one’s surprise, the levels of the two compounds are inversely related in aging.
....The molecular mechanism by which Nam works is very straightforward. Nam acts as a direct inhibitor of the SIRT1 enzyme pocket where NAD binds. Thus Nam is a “competitive inhibitor” of NAD and is “bad” when it comes to most cancers, aging, and most diseases.
On the other hand, inhibition of SIRT1 by Nicotinamide may be a “good thing” in the brain, where it may prevent NAD+ depletion and thereby protect neurons against excitotoxicity and neuronal cell death induced by PARP1.
....As the cell consumes NAD (by SIRT1-7, PARP1, PARP2, Tankyrases, CD38, CD157, ARTs, and other enzymes), the NAD is consumed, leaving the by-product, Nam. There are two primary ways of “disposing of Nam”. They are methylation/excretion or recycling of Nam into NMN (and subsequently NAD) via the “NAD salvage cycle”.
.....Conclusion: It is now clear that high concentrations nicotinamide are harmful to health. HIgh doses of dietary niacin probably produce the same effects, despite the many benefits of high dose niacin. With aging, nicotinamide levels already go up. Adding more nicotinamide is probably not going to “cure” aging. Adding a methyl donor to eliminate nicotinamide (such as betaine) may be a good thing.
Ciao
MA - r l i n
http://www.servizitelevideo.rai.it/televideo/pub/pagina.jsp?p=163&s=0&r=Nazionale&idmenumain=7&pagetocall=pagina.jsp
http://www.northwestern.edu/newscenter/stories/2015/04/telomere-changes-predict-cancer.html
e pure:
http://www.anti-agingfirewalls.com/2015/04/08/30-major-factors-that-control-sirt1-expression-sirt1-activity-and-sit1-mediated-aging-part-3-of-the-series-nad-an-emerging-framework-for-health-and-life-extension/
....The accumulation of excess nicotinamide in cells is probably a major cause of aging. Whereas we typically associate “NAD deficiency” with aging, “Nam excess” may have a similar effect. To no one’s surprise, the levels of the two compounds are inversely related in aging.
....The molecular mechanism by which Nam works is very straightforward. Nam acts as a direct inhibitor of the SIRT1 enzyme pocket where NAD binds. Thus Nam is a “competitive inhibitor” of NAD and is “bad” when it comes to most cancers, aging, and most diseases.
On the other hand, inhibition of SIRT1 by Nicotinamide may be a “good thing” in the brain, where it may prevent NAD+ depletion and thereby protect neurons against excitotoxicity and neuronal cell death induced by PARP1.
....As the cell consumes NAD (by SIRT1-7, PARP1, PARP2, Tankyrases, CD38, CD157, ARTs, and other enzymes), the NAD is consumed, leaving the by-product, Nam. There are two primary ways of “disposing of Nam”. They are methylation/excretion or recycling of Nam into NMN (and subsequently NAD) via the “NAD salvage cycle”.
.....Conclusion: It is now clear that high concentrations nicotinamide are harmful to health. HIgh doses of dietary niacin probably produce the same effects, despite the many benefits of high dose niacin. With aging, nicotinamide levels already go up. Adding more nicotinamide is probably not going to “cure” aging. Adding a methyl donor to eliminate nicotinamide (such as betaine) may be a good thing.
Ciao
MA - r l i n
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