The decrease in cystatin C indicates that high-dose creatine supplementation over 3 months does not provoke any renal dysfunction in healthy males undergoing aerobic training. In addition, the results suggest that moderate aerobic training per se may improve renal function.
http://www.ncbi.nlm.nih.gov/pubmed/18188581
Sicurezza di una supplementazione a lungo termine di creatina.
Parliamo di malati di Parkinson, nemmeno di atleti i quali potrebbero necessitarne una maggior quantita'.
http://www.hkmacme.org/course/2010BW03-05-00/GM%20CS_Mar%2010.pdf
Interessante questo passggio:
Although serum creatinine levels increased in Cr patients because of the degradation of Cr, all other markers of tubular or glomerular
renal function, especially cystatin C, remained normal, indicating unaltered kidney function.
Ancora:
http://www.scielo.br/scielo.php?pid=S1517-86922011000400004&script=sci_arttext&tlng=en
Interessante passaggio:
acute or chronic creatine supplementation (10 weeks) did not increase renal stress in healthy individuals, as evaluated by many serum and urinary markers(12,15,16). Likewise, adverse effects of creatine supplementation with low doses (1.5g) for prolonged periods (one to five years) on the renal function have not been reported either. Review studies(24-25) which analysed the short and long run renal and hepatic function with creatine supplementation did not find any alteration in the results of the same biochemical exams analysed in our study.
Moreover, when the renal function(16,26,27) and hepatic function(17,20,28), both in the short run with high doses and long run with low doses of creatine supplementation, did not observe any dysfunction. Bemben and Lammont(29) did not report any adverse effect in bibliographic review on the effects of creatine supplementation in many organs. The International Society of Sports Nutrition(30) concluded that creatine is safe, legal and efficient. Shao and Hathcock(4) evaluated the risk of creatine use in studies of medium (28 days) and long run (until one year), in which creatine supplementation followed in its great majority the 20 grams dose on the first week and 5g/day on the following ones. No adverse effect has been observed in studies involving healthy individuals as well as patients, proposing hence that the maintenance dose of 5g/day seems to be safe.