vi inoltro una risposta di ieri di greco
Please go to my blog hair grecohairblog.com for an explination of what
the
matrix is, how it works and a photo.
Also here is a recent post on the Bald Truth .com
Originally Posted by *Dr. Feller* [image: View
Post]<http://www.baldtruthtalk.com/showthread.php?p=4438#post4438>
Multiple HT's of the old variety can certainly decrease vascularity to a
significant degree. A lessor known consequence is that the skin of the
scalp
may also become chronically irritated from all the excess tissue -which
can
also limit hair growth.
PRP does increase vascularity and also decreases inflammation, so I
would
think that PRP would be a very appropriate therapy for someone in your
situation.
I honestly don't see how the extracellular matrix can make any
signficant
difference because. like LLLT, I don't see how it will get past the
epidermis and shallow dermis to get to the follicle in any signficant
concentration. While it may be effective in the body, I think it is at a
signficant disadvantage outside of the body. Also, ECM is Platlett Poor
Plasma which makes it less potent to begin with. I doubt it would make
much
of a difference even if it were injected.
Perhaps Dr. Joe Greco has some more insight on the matter, but for now I
see
no point in using ECM for treating hair or dermis.
I think these are great questions and Dr Feller is correct in how we
feel
PRP works on hair. Both PRP and GF/ECM complexes work on increasing hair
shaft and follicle density via vascularization of the follicle. We offer
both to patients.
Other than our study, two individual studies by (Yano, 2001) and
(Rinaldi,
2007) demonstrate growth factors, namely VEGF, increase vascularity to
the
follicle leading to increase in follicle and hair shaft size. Feed it
and
it will grow!
So I feel both PRP and GF/ECM complexes will have a positive influence
on
hair, but to answer the direct questions Dr Feller posed:
1- I don't see how it will get past the epidermis and shallow dermis to
get
to the follicle in any significant concentration. It is quite easy to
infuse the GF/ ECM complex into the dermis via creating thousands of
micro
channels through the epidermis into the dermis with a micro needling
roller.
Additionally, injecting the complex either in a retrograde fashion deep
to
superficial will infuse the complex through all layers of the scalp
including the dermis or it can be injected into the dermis. A layer of
activated GF'S are left on the scalp over night and when the epidermal
channels close the GF/ECM complex is entrapped in the dermis.
2- While it may be effective in the body, I think it is at a significant
disadvantage outside of the body. Independent studies conclude that,
GF-ECM
complexes may well be the most effective and efficient method to
stimulate
cell proliferation, as well as tissue healing or regeneration. Clark, R
et
al. Synergistic Signaling from Extra cellular Matrix-Growth Factor
Complexes. Journal of Investigative Dermatology (2008) 128, 1354-1355.
doi:10.1038/jid.2008.75.
3- Also, ECM is Platlett Poor Plasma which makes it less potent to begin
with. I doubt it would make much of a difference even if it were
injected.
This is true if you dilute PRP with only PPP, but our GF/ECM is achieved
by
a second concentrating processing of PPP and when mixed in a specific
ratio
with PRP and activated creates a natural protein matrix entrapping the
GF's inside the protein matrix. Because it takes the body longer to
break
down the protein the GF's remain in the treatment area longer to create
more
angiogenesis and mitogenesis.
The protein matrix allows new cells to attach to the cross linked
protein
fibers and independent studies indicate that less GF's are needed to
achieve
the same result as GF/ECM complexes. Upton et al. (2008)
Platelet Poor Plasma (PPP) is a disconcerting term because it has a
negative
connotation Poor. It should be called Protein Rich Plasma because it
has
tremendous advantages as demonstrated in our 072 patent because of the
level
of fibrin, fibrinonectin and vitronectin. (Upton et al. (2008)
demonstrate
that vitronectin (VN) complexes with insulin-like growth factor (IGF)
and
IGF-binding proteins (IGFBPs) could enhance migration of human
keratinocytes
in vitro and possibly in vivo.
So if you think of what hair is made of (protein), introducing a
Platelet
Rich concentration entrapped in a cross linked protein matrix is only
beneficial to hair.
I hope this clarifies my position and any misconceptions regarding PRP
and
GF/ECM complexes. Both PRP and GF/ECM complexes are positive for hair
and I
applaud Dr Feller for his use of PRP and support his continued use of
this
therapy. This type discourse is great for both clinicians and patients
and I
look forward to working with Dr Feller and others in investigating and
understanding newer technologies.
Finally, our experience in literally thousands of wound and soft tissue
cases since 1998 utilizing PRP and GF/ ECM complex demonstrate that the
GF/ECM complex are clinically superior. This is just the next step in
the
evolution of PRP as we will be adding peptides, stem cells and cultured
cells to this GF/ECM complex.
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------------------------------
Joe- Great summary of the ongoing therapies.
I want to thank you for being so willing to share your knowledge with
surgeons like Glenn Charles and myself- we are very excited to offer
this
therapy. My first case several weeks ago utilized both the PRP and the
PPP
(or we really need to come up with another abbreviation for Protein Rich
Plasma to distinguish it- perhaps PCP - protein concentrated plasma)
Jeff Epstein, MD, FACS
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On Thu, Jul 9, 2009 at 6:29 AM, Chicca <chicca@sicamtubi.com> wrote:
> Sorry f i disturb you, but as told y many people wonder about this
prp
> and ask what excatly are these grow factors in the matrix, can y give
me the
> details!
>
> Ai sensi del d.lgs 196/2003 si precisa che le informazioni contenute
in
> questo messaggio sono riservate e ad
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> eliminarlo senza copiarlo e a non inoltrarlo a terzi, dandocene
gentilmente
> comunicazione. Grazie
>
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chicca