io per farti un esempio leggendo i forum in cui si parla male di finasteride mi faccio suggestionare parecchio, ma la suggestione è qualcosa che non i frena più di tanto...è poi quando vedo che ci sono studi e prove scientifiche che supportano quelle mie suggestioni che un farmaco come la finasteride per me diventa tabù...non so se dare retta alla Merck che ci lucra sopra o a diversi studi di andrologi, endocrinolgi, neurologi che se finasteride la vendono o meno non gli entra in tasca nulla...non so se sai leggere l'inglese ma io quando leggo cose simili allora do retta al mio caro medico di famiglia che mi ha consigliato paternamente di stare alla larga da finasteride:
http://www.reference-global.com/doi/abs/10.1515/HMBCI.2010.010
The influence of low dose finasteride, a type II 5#945;-reductase inhibitor, on circulating neuroactive steroids
Michaela Dušková1,
Martin Hill1,
Luboslav Stárka1,
1Institute of Endocrinology, CZ 11694 Prague 1, Czech Republic
Corresponding author: MUDr. Michaela Dušková, PhD, Institute of Endocrinology, Národní 8, 116 94 Praha 1, Czech Republic Phone: +420-224905280, Fax: +420 224905325, email link
Citation Information. Hormone Molecular Biology and Clinical Investigation. Volume 1, Issue 2, Pages 95–102, ISSN (Online) 1868-1891, ISSN (Print) 1868-1883, DOI: 10.1515/HMBCI.2010.010, Available online: 17/09/2009, January 2010
Publication History: Received: 20/8/2009; accepted: 28/8/2009; published online: 17/09/2009
Abstract
Background: Finasteride is a 5#945;-reductase inhibitor that has received clinical approval for the treatment of human benign prostatic hyperplasia and androgenetic alopecia. The treatment is practically without side effects, although some occasional cases of depression syndrome have been reported. 5#945;-Reductase is an enzyme responsible for the reduction of testosterone, progesterone or deoxycorticosterone to their 5#945;-reduced derivatives possessing anticonvulsant, antidepressant, and anxiolytic activity. Therefore, the formation of GABAergic neuroactive steroids is likely to be impacted by finasteride.
Objective: The objective of the study was to show how the treatment of premature androgenetic alopecia with low doses (1 mg/day) of finasteride influences the broad spectrum of steroids with potential neuroactivity.
Methods: A group of 12 men with premature androgenetic alopecia participated in the present study. The steroid hormone profile was determined for all individuals. Finasteride was administered for 4 months at a daily dose of 1 mg. After the treatment, the same hormonal profile was determined again.
Results: 5#945;-Reduced steroids, e.g., 5#945;-dihydrotestosterone, androsterone, epiandrosterone, 5#945;-androstene-3#945;,17#946;-diol, allopregnanolone, isopregnaolone, and some 5-ene steroids, such as dehydroepiandrosterone and pregnenolone, decreased gradually during treatment.
Conclusions: The decrease of 5#945;-reduced steroids, especially of allopregnanediol, dihydrotestosterone, and pregnenolone, is probably one of the factors responsible for the increased occurrence of depression in men treated with finasteride, even at low doses.
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