Non sono esperta e non mi permetterei mai di sostituirmi ad un dottore, ma credo che nel valutare la tossicità di un farmaco, siano sempre da valutare le dosi assunte. Per la flutamide si parla di 3 compresse da 250 per il cancro alla prostata e di 125 ( cioè mezza pastiglia per irsutismo). Non posso pensare che gli effetti collaterali siano gli stessi e con le stesse incidenze !!
vi sembra sbagliato come ragionamento ?
Side effects
The disadvantages of this drug include foul urination, extreme dry skin and hair scalp, reduced libido, heightened appetite, liver enzyme disorders, and, rarely, lethal hepatotoxicity. In fact, its unpopularity as an androgen blocker is entirely because of its rare but serious side effect of potentially deadly hepatotoxicity. Moreover, it is an expensive treatment too.
Modern research suggests the administration of lower doses of flutamide in hirsutism treatment in order to reduce costs and chances of hepatotoxicity.
In one such survey conducted on 35 hirsute females, flutamide used in a daily dose of 250 mg for 6 months resulted in a 64 percent reduction in the Ferriman–Gallwey (F–G) scoring system of hirsutism and 71 percent after therapy for a year. The best news was that there were no cases of hepatotoxicity and marked side effects either.
Simultaneously, the same survey was conducted with lower daily doses of the drug on many more hirsute patients. They too came up with similarly effective decrease in unwanted and excess hair production after 3 and 6 months of therapy with 125 mg and 62.5 mg of medication. Again, there were no reports of considerable side effects. Some other clinical investigations however mentioned side effects like dry skin and discolored urine.
In hirsute cases with polycystic ovarian syndrome, continued flutamide doses of 500 mg daily for 2 years did not result in major side effects either. This survey noticed substantial improvement of F–G scores after 6 months of treatment and a progressive decline during another 18 months of treatment.