http://dx.doi.org/10.1016/j.ejps.2009.03.002
Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication
Hwa Jung Choia, Jae Hyoung Songb, Kwi Sung Parkc, Dur Han Kwona,#8727;
a Immune Modulator Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Republic of Korea
b Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan 570-749, Republic of Korea
c Chungcheongnam-Do Health and Environment Research Institute, Daejeon 300-801, Republic of Korea
a r t i c l e i n f o
Article history:
Received 16 January 2009
Accepted 2 March 2009
Available online xxx
Keywords:
Quercetin 3-rhamnoside (Q3R)
Houttuynia cordata
Antiviral activity
Influenza
a b s t r a c t
Influenza viruses cause significant morbidity and mortality in humans through epidemics or pandemics.
The lack of effective therapeutical treatment underlines the importance of research for newantiviral compounds. Flavonoids widely exist in the plant kingdom, and their antiviral activities against various viruses have been recently reported. In this study, the anti-influenza A/WS/33 virus of quercetin 3-rhamnoside (Q3R) from Houttuynia cordata was evaluated using a cytopathic effect (CPE) reduction method, the assay results demonstrated that Q3R possessed strong anti-influenza A/WS/33 virus reducing the formation of a visible CPE. Q3R also did inhibit virus replication in the initial stage of virus infection by indirect interaction with virus particles. However, oseltamivir has relative weaker efficacy compared to Q3R. Therefore, these findings provide important information for the utilization of Q3R for influenza treatment. © 2009 Elsevier B.V. All rights reserved.
http://dx.doi.org/10.1016/j.bmc.2008.06.049
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