nuovi anti-sides

[juliensorel]

Effects Of Acute Prolactin Manipulation On Sexual Drive And Function
Posted: 12 Jul 2012 10:49 AM PDT

Kruger TH, Haake P, Haverkamp J, et al. Effects of acute prolactin manipulation on sexual drive and function in males. J Endocrinol 2003;179(3):357-65. http://joe.endocrinology-journals.org/content/179/3/357.full.pdf

The neuroendocrine response to sexual activity in humans is characterized by a pronounced orgasm-dependent increase of plasma levels of prolactin. In contrast to the well-known inhibitory effects of chronic hyperprolactinemia on sexual drive and function, the impact of acute prolactin alterations on human sexual physiology is unknown. Therefore, this study was designed to investigate the effects of acute manipulation of plasma prolactin on sexual behavior.

Ten healthy males participated in a single-blind, placebo-controlled, balanced cross-over design. Prolactin levels were pharmacologically increased to high levels (protirelin, 50 micro g i.v.) or reduced to low physiological concentrations (cabergoline, 0.5 mg p.o.). Sexual arousal and orgasm were then induced by an erotic film and masturbation. In addition to continuous neuroendocrine and cardiovascular recordings, the quality and intensity of the acute sexual drive, arousal, orgasm and refractory period were assessed by extensive psychometric measures.

Administration of cabergoline decreased prolactin levels and significantly enhanced all parameters of sexual drive (P<0.05), function (P<0.01) and positive perception of the refractory period (P<0.01). Administration of protirelin increased prolactin concentrations and produced small, but not significant reductions of sexual parameters. The sexual effects observed from cabergoline were completely abrogated by coadministration of protirelin.

Although different pharmacological sites of action of prolactin-altering drugs have to be considered, these data demonstrate that acute changes in prolactin plasma levels may be one factor modulating sexual drive and function. Therefore, besides a neuroendocrine reproductive reflex, a post-orgasmic prolactin increase may represent one factor modulating central nervous system centers controlling sexual drive and behavior. These findings may offer a new pharmacological approach for the treatment of sexual disorders.

 

[juliensorel]

http://en.wikipedia.org/wiki/Cabergoline

 

[soul]

Una traduzione per chi non mastica affatto l'inglese?[]

 

[csongrad]

ah, quindi cabergolina a 0,5mg, solitamente a 1mg esistono sides frequenti (accusati più da donne però mi sembra)

 

[marlin]

E' la sezione naturali....ed è sempre meglio non indicare farmaci, anche perché qui si è parlato già di sostanze non sintetiche che hanno questo effetto (agnocasto, asa foetida, ginkgo...).

Ciao

MA - r l i n

 

[crack]

Provata la bromocriptina anni fa che e' molto simile alla cabergolina, tranne per il fatto che i sides su taluni sono piu' accentuatu.
Libido annichilita, orgasmi super veloci ed improvvise moscezze del mio tool nel bel mezzo del rapporto.
Appena interrotta la mia vita sessuale dopo pochi giorni e' tornata alla normalita'.
Approfondii la cosa e trovai uno studio, postato anche qui su Ieson, dove si diceva a chiare lettere che la prolattina molto bassa diminuiva il testosterone.
Poi una singola ingestione potrebbe cambiare qualcosa rispetto ad un ciclo di un mese come feci io, ma certo che quegli orgasmi fulminei...

 

[juliensorel]

>>sempre meglio non indicare farmaci

vabbé questa è una sostanza derivata da una naturale (ergotina)-
Ad ogni modo la distinzione manichea tra naturale e di sintesi è del tutto fuorviante.

 

[marlin]

Sì, ma questa sezione che ci starebbe a fare se non si distingue tra farmaci e non ?

Posso solo dirti che su questo farmaco ero già incappato proprio cercando degli antiprolattinici (ma non l'ho postato appunto perché un farmaco...) però ho cercato i corrispondenti naturali.

I derivati dell'ergot sono tra le sostanze naturali più problematiche, si tratta infatti della famigerata segale cornuta (mica niente....):

http://it.wikipedia.org/wiki/Claviceps_purpurea

Ciao

MA - r l i n

 

[crack]

La selegilina e' ben conosciuta per l'effetto su libido ed erezione, io cabergolina e bromocriptina non le toccherei con un bastone lungo 3 metri...

 

[pccion]

brutta cosa la moscezza e la supermega venuta a presa rapida...


cazzacci!

ne starei lontano pure io

 

[crack]

Guarda, la provai piu' per curiosita' che per reale bisogno, ovunque leggevo dei presunti effetti positivi su libido, diminuzione del periodo refrattario ecc.
So solo che con la mia ex dei tempi, durante quel mese, feci delle figure magrissime e non riuscivo a capacitarmi.
Orgasmi della durata di un minuto di orologio (!) o il pene che improvvisamente perdeva l'erezione...
Mai piu' avuta una esperienza del genere, di anni ne ho 33 e come ho detto la mia sessualita' e' sempre stata intensa e appagante.

 

[pccion]

ci credo! anche a me è capitato in passato di fare esperimenti, e il mio corpo in un modo o nell'altro si è fatto sentire all'istante!

 

[prolo]

Esattamente i sintomi che mi provaoca la finasteride, Crack.. lui che si ammoscia proprio a metà dell'opera e orgasmi veloci, o meglio pre-orgasmi ai quali segue regolare ammosciamento.. forse il meccanismo è lo stesso degli anti dht?

 

[juliensorel]

No, non influiscono con il DHT sono degli antagonisti della prolattina, un ormone secreto dall'ipofisi. Troppa prolattina nuoce alla libido. Il punto è che sono sostanze molto selettive.

 

[crack]

Anche la prolattina troppo bassa nuoce alla libido.

 

[crack]

Experientia 1984 Jan 15;40(1):88-9

Effects of bromocriptine on plasma testosterone and gonadotropin levels and testicular lipid fractions in adult rats.

Rao MR, Bartke A.

Bromocriptine treatment of adult male rats resulted in a decrease in testicular testosterone (T) content and a reduction in plasma T levels. This was accompanied by increase in testicular total lipids and cholesterol and depletion of testicular phospholipids.



Fertil Steril 1991 Feb;55(2):355-7

Effects of chronic bromocriptine-induced hypoprolactinemia on plasma testosterone responses to human chorionic gonadotropin stimulation in normal men.

Oseko F, Nakano A, Morikawa K, Endo J, Taniguchi A, Usui T.

Department of Medicine, Shimane Medical University, Japan.

To study the role played by normal levels of plasma prolactin (PRL) in the secretion of testosterone (T) in the testes, we induced hypoprolactinemia with a daily dose of 5 mg bromocriptine administered orally in five normal men 20 to 35 years of age for 8 weeks. The basal PRL, T, luteinizing hormone, follicle-stimulating hormone, and maximum responses of plasma T to human chorionic gonadotropin (hCG) stimulation were measured every 2 weeks.Basal levels of plasma T were reduced in the 1st 2-week-long period of hypoprolactinemia. In the 4-week-long period of hypoprolactinemia, the maximal response of plasma T to hCG stimulation was significantly reduced. The findings suggest that normal levels of plasma PRL may play an important role in the secretion of T in the human testes in vivo.


Andrologia 1990 May-Jun;22(3):251-9

Effect of modulating endogenous prolactin secretion on testosterone production in the adult male bonnet monkey (Macaca radiata).

Rao AJ, Rani CS, Ravindranath N, Moudgal NR.

Department of Biochemistry, Indian Institute of Science, Bangalore.

Adult male bonnet monkeys maintained under regulated light: dark conditions exhibit a nycthemeral surge of testosterone. The present study attempts to determine the effect of administration of drugs that modulate prolactin levels like ergobromocriptine (EBC) and chlorpromazine (CPZ) on testosterone production.The injection of EBC, a known inhibitor of prolactin secretion, could abolish nocturnal testosterone surge irrespective of the drug being given at 8.00 or 17.00 h. Testosterone surge could likewise be inhibited by treating animals with CPZ, a potent stimulator of prolactin secretion. This suggests that alteration in endogenous prolactin level from the normal effects nycthemeral surges of testosterone. The in vivo responsiveness of the testes of monkeys injected either CPZ oder EBC to exogenous LH or LHRH stimulation was tested. While LH could completely override the CPZ induced inhibition in testosterone production it could only partially reverse the EBC effect.



Nippon Naibunpi Gakkai Zasshi 1985 Jun 20;61(6):701-9

The effects of bromocriptine on the pulsatile pattern and the circadian profile of gonadotropins and testosterone secretion in normal adult men

Aisaka K, Ogawa T, Mori H, Kigawa T.

To investigate the effects of bromocriptine on the secretion mechanism of pituitary gonadotropins and testosterone, 5 mg of bromocriptine was administered to five young adult men who were normal in their endocrinological states. Blood samplings were taken from two hours before until six hours after the administration every 15 min., and after that, blood samplings were continued until 21 hours every one hour by an intravenous indwelling catheter. Serum FSH, LH, prolactin and testosterone levels were determined by RIA, and the changes of the pulsatile patterns of FSH and LH, and the circadian profile of these hormones by the administration of bromocriptine were analysed. Serum prolactin levels decreased significantly (p less than 0.005) from two hours after the administration of bromocriptine and remained in a very low range until the end of the experiment. The basal levels of FSH showed a significant decrease from two to six hours after the administration (p less than 0.005). Also the basal levels of LH showed a significant decrease from two to six hours after the administration (p less than 0.005). However, the basal levels of serum FSH and LH did not show significant decreases after that until the end of the experiment. No significant change was observed in the amplitude or the frequency of the pulsatile patterns of FSH and LH until six hours after the administration of bromocriptine. The serum levels of testosterone were also significantly decreased from two to six hours after the administration (p less than 0.005), but they did not show a significant decrease after that until the end of the experiment.

 

[marlin]

La prolattina serve ad evitare l'eiaculazione precoce, quando e' ai livelli giusti.

Ciao

MA - r l i n