News: New article about Ketocazole (Nizoral) as an adjuct to the treatment of androgenetic alopecia (hair loss)
A new article has been published in 'Medical Hypotheses' Volume 62, Issue 1, 2004, Pages 112-115, that gives more ammunition to the idea of adding Nizoral to your hair loss treatment regimen.
Here is the abstract:
Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men
B. S. Hugo Perez
California College of Podiatric Medicine, 371 Columbus Avenue, San Francisco, CA 94133, USA
Received 5 June 2002; accepted 11 November 2002. ; Available online 18 December 2003
Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (AGA). Testosterone is converted to DHT by the enzyme 5-alpha-reductase. Finasateride a 5-alpha-reducase inhibitor blocks the production of DHT and is currently used to treat AGA. The inhibition is not complete but a reduction of DHT systemically and in the scalp is accomplished. Ketoconazole has been clinically shown to be effective in the treatment of AGA. In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat AGA.
Read the full-text article here:
http://www.sciencedirect.com/scienc...=1022551&md5=c8073d291e4994066a43b9739b67939c
A new article has been published in 'Medical Hypotheses' Volume 62, Issue 1, 2004, Pages 112-115, that gives more ammunition to the idea of adding Nizoral to your hair loss treatment regimen.
Here is the abstract:
Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men
B. S. Hugo Perez
California College of Podiatric Medicine, 371 Columbus Avenue, San Francisco, CA 94133, USA
Received 5 June 2002; accepted 11 November 2002. ; Available online 18 December 2003
Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (AGA). Testosterone is converted to DHT by the enzyme 5-alpha-reductase. Finasateride a 5-alpha-reducase inhibitor blocks the production of DHT and is currently used to treat AGA. The inhibition is not complete but a reduction of DHT systemically and in the scalp is accomplished. Ketoconazole has been clinically shown to be effective in the treatment of AGA. In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat AGA.
Read the full-text article here:
http://www.sciencedirect.com/scienc...=1022551&md5=c8073d291e4994066a43b9739b67939c
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