L'acaro Demodex f o l l i c u l o r u m

[kafir]

Citazione:Thread: The Demodex Thread

Message Date: Apr 5, 2006 10:28 PM
Hi Everyone, I want to start by thanking you all for your genuine interest in this subject. I am going through the hard drive of my old pc and I am finding the files to be, quite frankly, a mess. I am new posting here and am not fully up to speed on making good posts (use of italics, bold fonts, etc), so please understand. I am going through things one at a time to look for applicability. If you really want to search the archives for good intelligent studies on the relationship between demodex and hair loss, I am afraid you will be disappointed. There is some ancillary research, but no one has really just killed them on balding men and took a look what happened. The reality is that anyone one can try without a research grant or contract with a big pharma player. Below is the text (pdf with footnotes #s deleted) from a short article by a guy named
Larry E. Millikan, MD, New Orleans, LA.
It was done in 2001. And is really the only paper I found that looks at demodex and hair loss. His last statement reads in this paper reads: “We find these initial results intriguing, suggesting that Demodex is a factor, not an epiphenomenon, and intend to follow up with these studies using sequential evaluations to determine if manipulation of the Demodex population would alter the process of progressive androgenetic alopecia. Further studies will be forthcoming.” Why no follow-up after almost 5 years? Want to bet Larry is too busy with new theories to bother with one that has so little, how can I say it, financial promise. Anyway some one should track this guy down and ask he what’s going on with his research, because I cannot find any more on this subject from him. Here is the full text below. I have highlighted (I thought I did, but next time) some items of interest. Let this be the first instalment of the demodex papers.

Dex Androgenetic alopecia: the role of inflammation and Demodex (International Journal of Dermatology 2001, 40, 472-484) The focus on androgenetic alopecia has been increasing in the last decade because of the availability of new, scientifically valid therapies such as Rogaine (Minoxidil) and Propecia (Finasteride). Hamilton showed in 1951, that 50% of men, and 40% of women demonstrated androgenetic alopecia by age 50.1 In 1993, 40% of men, and 30% of women sh

 

[kafir]

Citazione:Thread: The Demodex Thread

Message Date: Apr 5, 2006 10:28 PM
Hi Everyone, I want to start by thanking you all for your genuine interest in this subject. I am going through the hard drive of my old pc and I am finding the files to be, quite frankly, a mess. I am new posting here and am not fully up to speed on making good posts (use of italics, bold fonts, etc), so please understand. I am going through things one at a time to look for applicability. If you really want to search the archives for good intelligent studies on the relationship between demodex and hair loss, I am afraid you will be disappointed. There is some ancillary research, but no one has really just killed them on balding men and took a look what happened. The reality is that anyone one can try without a research grant or contract with a big pharma player. Below is the text (pdf with footnotes #s deleted) from a short article by a guy named
Larry E. Millikan, MD, New Orleans, LA.
It was done in 2001. And is really the only paper I found that looks at demodex and hair loss. His last statement reads in this paper reads: “We find these initial results intriguing, suggesting that Demodex is a factor, not an epiphenomenon, and intend to follow up with these studies using sequential evaluations to determine if manipulation of the Demodex population would alter the process of progressive androgenetic alopecia. Further studies will be forthcoming.” Why no follow-up after almost 5 years? Want to bet Larry is too busy with new theories to bother with one that has so little, how can I say it, financial promise. Anyway some one should track this guy down and ask he what’s going on with his research, because I cannot find any more on this subject from him. Here is the full text below. I have highlighted (I thought I did, but next time) some items of interest. Let this be the first instalment of the demodex papers.

Dex Androgenetic alopecia: the role of inflammation and Demodex (International Journal of Dermatology 2001, 40, 472-484) The focus on androgenetic alopecia has been increasing in the last decade because of the availability of new, scientifically valid therapies such as Rogaine (Minoxidil) and Propecia (Finasteride). Hamilton showed in 1951, that 50% of men, and 40% of women demonstrated androgenetic alopecia by age 50.1 In 1993, 40% of men, and 30% of women sh

 

[kafir]

Citazione:Thread: The Demodex Thread

Message Date: Apr 5, 2006 10:28 PM
Hi Everyone, I want to start by thanking you all for your genuine interest in this subject. I am going through the hard drive of my old pc and I am finding the files to be, quite frankly, a mess. I am new posting here and am not fully up to speed on making good posts (use of italics, bold fonts, etc), so please understand. I am going through things one at a time to look for applicability. If you really want to search the archives for good intelligent studies on the relationship between demodex and hair loss, I am afraid you will be disappointed. There is some ancillary research, but no one has really just killed them on balding men and took a look what happened. The reality is that anyone one can try without a research grant or contract with a big pharma player. Below is the text (pdf with footnotes #s deleted) from a short article by a guy named
Larry E. Millikan, MD, New Orleans, LA.
It was done in 2001. And is really the only paper I found that looks at demodex and hair loss. His last statement reads in this paper reads: “We find these initial results intriguing, suggesting that Demodex is a factor, not an epiphenomenon, and intend to follow up with these studies using sequential evaluations to determine if manipulation of the Demodex population would alter the process of progressive androgenetic alopecia. Further studies will be forthcoming.” Why no follow-up after almost 5 years? Want to bet Larry is too busy with new theories to bother with one that has so little, how can I say it, financial promise. Anyway some one should track this guy down and ask he what’s going on with his research, because I cannot find any more on this subject from him. Here is the full text below. I have highlighted (I thought I did, but next time) some items of interest. Let this be the first instalment of the demodex papers.

Dex Androgenetic alopecia: the role of inflammation and Demodex (International Journal of Dermatology 2001, 40, 472-484) The focus on androgenetic alopecia has been increasing in the last decade because of the availability of new, scientifically valid therapies such as Rogaine (Minoxidil) and Propecia (Finasteride). Hamilton showed in 1951, that 50% of men, and 40% of women demonstrated androgenetic alopecia by age 50.1 In 1993, 40% of men, and 30% of women sh

 

[kafir]

ATLANTA, GA, March 4, 1998 � NIOXIN#65533; , a therapeutic hair-care company, has introduced a line of products called SEMODEX#65533; , created in response to new research that found a link between thinning hair and an enzyme produced by a common mite. These products, available in April in salons worldwide, inhibit the action of and remove the enzyme lipase from the scalp.

In a study conducted by NIOXIN researchers, lipase was found in the hair follicles of 50 men and women with thinning hair. Lipase adversely affects the condition of the hair and scalp, and removing it helps to create fuller, thicker and healthier hair. NIOXIN researchers discovered it and the mite that produces it, Demodex follic**orum, in the scalp by using a newly created hand-held microscope, a Nioscope, which magnifies hair follicles up to a thousand times.

Our discovery of the impact of lipase on the human scalp is significant, and we think both our customers and our salon operators will find the SEMODEX line equally ground-breaking, said Roy Bashforth, co-founder of NIOXIN. The SEMODEX line consists of cleansers and scalp serums. The cleanser shampoos away lipase from the scalp skin, and the scalp serum inhibits the action of lipase, helping to create healthier hair and scalp. Results of the NIOXIN study were announced at a recent international symposium of dermatologists by Dr. William Regelson, director of the Successful Aging Program at Virginia Commonwealth University�s School of Medicine.

Discovering the impact of lipase on scalp and hair care will forever change the way we look at the thinning-hair issue, said Dr. Regelson. We�re now one step closer to helping the 70 million Americans who are plagued by this problem.

Demodex is believed to appear during adolescence and is present in almost all adults by middle age. Regular shampoos, conditioners, and anti-dandruff products do not remove the lipase produced by the mite.

http://www.madison-avenue.com/Products/Nioxin/nioxin_main_semodex.htm


Demodex extraction from follicle
http://www.madison-avenue.com/AVI/demodex.avi

Demodex seeking follicle on scalp
http://www.madison-avenue.com/AVI/demodex2.avi

 

[kafir]

http://www.omisega.com/beauty/dani/index.htm

 

[marlin]

L'argomento, anche se ogni tanto torna di nuovo a galla, è vecchiotto, i prodotti Nioxin sono considerati ottimi, ma non hanno risolto (come si diceva nella pubblicità di quegli anni) il problema della calvizie. Il Demodex probabilmente si trova a suo agio sullo scalpo alopecico[]

Ciao.

MA - r l i n

 

[haga]

Ammazza che schifo!!!

 

[claudia]

fantastico!
Abbiamo uno zoo in testa...
Comunque a me fanno ancora più schifo gli acari della polvere, che infestano lenzuola e materassi...

bleah....

 

[kafir]

Di cosa è composto Semodex?
Scritto, che l'acido azelaico può farli fuori, ma lo stesso funziona anche come antiandrogeno.

 

[kafir]

A Bit of Background
Demodex F o l l i c u l o r u m, also know as Demodicids, are a species of tiny mite that some researchers have recently identified as a profound contributor to hair loss. While we believe that there are other factors affecting those with hair loss, such as diet, genetics, and chemical laden hair care products, many researchers attribute this microscopic critter with much more than just a small role in the plight of hair loss. Demodex has also been called “face mite” as it has been commonly associated with various skin complications of the face, such as Acne Rosacea, blackheads, and other skin irritations. demodex follic**orum

Varying in size from .1mm to .4 mm long, it lives in your pores and hair follicles, typically on your scalp, cheeks, nose, eyebrows and often in the roots of your eyelashes. Demodicids have worm-like attributes, with tiny claws, and scales over the whole of its body so that it may better anchor itself in the hair follicle. An individual female may lay up to 25 eggs in a single follicle, and as the mites grow, they become tightly packed. When mature, the mites leave the follicle, mate, and lays more eggs. During the day, Demodex mites remain feeding within the follicle. At night, they emerge onto the surface to mate, and eggs are laid into follicles so that the newly hatched larvae may feed on sebaceous oils.



Disturbing Research

Demodex F o l l i c u l o r u m was first discovered in human hair by a researcher at Nioxin, a major hair-care and cosmetics manufacturer, thanks to a newly developed, hand-held, high powered microscope capable of magnifying the human scalp up to 1000 times. What did he see? As many as a dozen mites, burrowed head down in the hair follicles, feasting off the oily secretions of the scalp known as sebum. Nioxin Research Laboratories in collaboration with Tulane University, pointed out that, of individuals with thin-looking hair, 88% have Demodex F o l l i c u l o r u m. In contrast, only 9% of tested individuals with normal hair density had Demodex Follic**orum.

demodex nested in hair follicle According to one dermatologist, Dr. William Regelson, an expert with the Medical College of Virginia, the mite has been known since the 1840s to cause mange in animals, and until now no one had noticed that the minute organism known as Demodex Follicu-lorum is invariably present in the hair follicles of human beings who are losing their hair. Apparently Demodex can arrive in adolescence, and by late to middle age all almost all people harbor the Demodex mite to some degree.

Researchers say that in people up to 20 years of age, the incidence was about 25%; in people up to 50 years of age, the incidence was 30%; in people up to 80 years of age, the incidence was 50%; and in those aged 90 or older, everyone has it.

So then the million dollar question – wouldn't everyone be losing their hair? The answer is not so clear-cut.



Determining Factors - Who is Affected?

So if the presence of the mite is so rampant, why doesn’t hair loss affect everyone who harbors the mite? Varying opinions have been given towards this subject, however we will only cover the two most relevant ones here.

The most widespread explanation is that some of us have the unfortunate gene that may cause an immune response that is not necessarily uniform across all those who are affected with the mite. Respectfully their body reacts to the existence of the mites and instigates an inflammatory response as it tries to rebuff the mites. Unfortunately, when the inflammatory process kicks in and blocks the hair follicle and killing the mite—it also kills the hair follicle.

The second most common reasoning is the level of infestation taking place. As the Demodex mite feeds off of sebum produced by the sebaceous glands, the hair follicle can become progressively undernourished causing the hair follicle to eventually fall out. Several Demodex mites can feast off of a single hair follicle, so the resulting effect is that there are just too many mouths to feed at the table, and the hair follicle eventually suffers.

http://www.jashbotanicals.com/articles/demodex_follic**orum.html

 

[proxy]

Del Demodex,si dibatte tuttora,non si sa ancora per certo se puo' o meno essere legato alla caduta dei capelli.
La cosa certa e' che appunto,si nota maggiormente nella cute di chi ha l'androgenetica.
Nioxin da tempo ha messo a punto un sistema per eliminare la lipasi prodotta dal Demodex,si chiama Semodex.La lipasi sarebbe dannosa per la salute dei capelli.
Non avendo pero' alcuna certezza che la sua eliminazione porta ad un miglioramento della situazione capelli,la sua validita' e' ancora tutta da provare.

ciauzzzz[8D]

 

[ronald]

ca**o ma si vede? e se ce l'ho e non lo so? bohhhhhhhhhh

 

[magnolia]

HO I BRIVIDI...........NON AVREI MAI IMMAGINATO CHE FOSSE POSSIBILE AVERE IN TESTA UNA COSA COSI' ....SCHIFOSA. PENSATE SIA POSSIBILE CHE PROVOCHI LA CADUTA DEI CAPELLI??? QUESTO SHAMPOO PUò ESSERE USATO ANCHE IN MANIERA PREVENTIVA?? RAGAZZI IN QUESTO CASO ERA MEGLIO CHE NON SAPESSI. VEDERE LE IMMAGINI DEGLI ACARI CHE HA TESTA IN GIU' SI INFILANO NEL BULBO MI DARA' GLI INCUBI A LUNGO. DOTTORE LEI COSA NE PENSA?? POSSONO FAVORIRE LA CADUTA?? CIAO A TUTTI

 

[kafir]

io invece ho comprato Skinoren 20%, visto, che oltre fare fuori sti acari è un inibitore di alfa-5-reduttasi, sto cominciando a usarlo minimo per 60 giorni, visto che non ho niente da abbinare al minoxidil 5%, oltre olio di lino[8)]

Citazione:Clinical Pharmacology: The exact mechanism of action of azelaic acid is not known. The antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis. Azelaic acid at high concentrations is bactericidal against Propionibacterium acnes and Staphylococcus epidermis and possesses bacteriostatic properties against a variety of aerobic microorganisms, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. In vitro, azelaic acid acted as a scavenger of oxy radicals and inhibits a variety of oxidoreductive enzymes including 5-alpha reductase, the enzyme responsible for converting testosterone to DHT. Azelaic acid (0.1 to 3.0 mmol/l) has been shown to produce a competitive concentration dependent inhibition of 5-alpha reductase activity in homogenates of human foreskin. Azelaic acid is being studied for potential antimycotic and antiviral properties. The multiple actions of azelaic acid cause a normalization of keratinization and a decrease in the free fatty acid content of skin surface lipids.

Pharmacodynamics: Following a single application to human skin, 3 to 5% of the azelaic acid penetrates into the strateum corneum (up to 10% is present in the dermis and epidermis). There is negligible cutaneous metabolism after topical application. Approximately 4% of topically applied azelaic acid is systemically absorbed and mainly excreted unchanged in the urine. The half-life is approximately 12 hours after topical dosing, indicating percutaneous absorption rate-limited kinetics. After topical treatment with azelaic acid, plasma concentration and urinary excretion are not significantly different from baseline levels.

 

[blood]

scusa kafir, ma come fai ad applicare lo skinoren su tutto il cuoio capelluto, visto che una crema? non sarebbe meglio un galenico liquido dello stesso in modo da poterlo applicare anche nelle zone dove ci sono i capelli?[X]

 

[kafir]

infatti, io ho una situazione, quale mi permette di applicare la crema senza grossi perdite della sostanza,
(http://volosy.com/forum/album_pic.php?pic_id=26 )

la crema si assorbe molto bene ed anche velocemente,
i capelli basta pettinare in tempo, allora la crema andata su capelli fa effetto gel,
(non puzza, non unge, tienie capelli in forma)

credo, che per distribuire meglio, bisogna diluire la crema con qualche cosa,
cerchero di farlo con il solito alcool

 

[marlin]

Comunque di animaletti simili è pieno il nostro corpo, l'esperto in nanotecnologie che mi ha contattato all'inzio di quest'anno li utilizza proprio per veicolare alcune molecole di farmaco, per esempio quelle che servono a guarire l'acne.

Poi la lotta alla lipasi, kafir, è controproducente se usi l'olio di lino, perchè è questo enzima che lo idrolizza e lo scinde possibilmente in acidi grassi liberi quindi l'effetto benefico per il capello degli olii potrebbe essere dato proprio da questo enzima.

Il demodex è di casa soprattutto sulle ciglia e le sopracciglia che difficilmente cadono, inoltre non si capisce come possa agire in un modo sullo scalpo maschile e in un altro su quello femminile (due diversi pattern alopecici).

Infine, io uso acido azelaico in una forma o nell'altra da due anni ormai, ma non ho avuto ricrescita nelle zone dove ce ne era più bisogno. Il demodex viene stroncato peraltro del tutto dalla pilocarpina in gel.

Ciao.

MA - r l i n

 

[kafir]

Dici da 2 anni, che usi azelaico?? Ogni giorno?
Io ho ordinato FINACEA, peccato che non sapeva di questo gel ieri, comunque voglio vedere che succede, se non si fara nulla in 90 giorni insieme al minoxidil 5%, vado a procurarmi l' eucapil.

Il olio di lino mi serve soltanto come antiandrogeno + fonte precursore per GLA.

Ho letto un mucchio di cose in ultime 3 settimane, la più curiosa sara questa:
Citazione:
Recently, it was noted that follicles from balding areas of persons with androgenetic alopecia are able to produce terminal hairs when implanted into immunodeficient mice. This suggests that systemic or external factors may play a role in this disorder.
http://www.emedicine.com/derm/topic21.htm

che mi produce assoluta sicurezza nelle azioni di eliminare sti creature,
magari è arrivato il giorno, quando bisognerà pronunciare forte:
si lavano i denti è capelli ogni giorno

 

[bob1]

Ho scoperto il modo per uccidere i dannati esseri...Bisogna usare l'insetticida invece che la lacca![ov][ov][sp][sp][]

 

[kafir]

oltre acido azelaico basterebbe una sciaquata con il collutorio antibatterico che si usa per la igiene orale, credo