Ciao a tutti!
indagando indagando incuriosito sulle fulvine...mi sa che e piu facile che si tratti di questo..se si parla di giuliani...Fulvine(usano il marchi ma il P.A. e un altro)..vedendolo in farmacia dicono che e stata presentata al congresso 2008 ifscc...(sulla scatola)
da:
IFSCC conference Barcellona 2008
Novel retinol-like actives from parrots feathers / M. Rigano, M. Picaro, E. Pini, R. Stradi, M. Meloni, A. Bertelli, A. Benedusi, G. Giuliani. - In: IFSCC magazine. - ISSN 1520-4561. - 11:4(2008). - p. 323-330
ho trovato:
14th Meeting of the
European Society for Pigment Cell Research
(ESPCR - 2007)
Briganti S. Flori E., Camera E., Pini E., Stradi R., Benedusi A., Giuliani
G., Bertelli A., Picardo M.
Novel pigments from parrot feathers with antioxidant and photoprotective
actions
POI
da:
39th Annual Meeting of the
European Society for Dermatological Research
09-12 September 2009, Budapest, Hungary
The anti-apoptotic activity of psittacofulvins in transplanted hair bulbs
Giuliani G1, Rinaldi F2 1Giuliani SPA, Milan, Italy 2International Hair Research
Foundation, Milan, Italy
The anti-apoptotic activity of a new compound with a carotenoid-like structure was
studied. This compound has been recently isolated chemically as a result of studies
on the pigments present in a particular species parrots.This new class of pigment,
which are also called Psittacofulvins, have been proved to possess interesting
biological properties that differ from those that carotenoids are known to have. To
evaluate the anti-apoptotic efficacy on dermal papilla of this compound we studied
the effect on transplanted bulbs during hair transplants, like a model of induction
of apoptosis of hair bulbs, because the evidence of the hair follicle damage during
a transplantation is clear. We made a double blind randomized clinical trial on 50
men, volunteers, underwent an hair transplant (micro-mini grafts, FUE) in androgenic
alopecia and treated with a topic solution (nanospheres) with psittacofulvin once a
day, from 15 days before hair transplant to 90 days after transplantation.To study the
effect of psittacofulvins we used an experimental design evaluating: 1) the number
of apoptotic fragments 2) changes in the mitotic activity in the hair follicles before
and after transplantation. Quantification of apoptotic fragments in transplanted hair
follicles is a sensitive and accurate assay of hair follicle damage. Our results show a
very important anti-apoptotic activity of psittacofulvin in transplanted bulbs
poi
DA:
ARCHIVIO ISTITUZIONALE RICERCA UNIMI
Biological activity of parrodienes, a new class of polyunsaturated linear aldehydes similar to carotenoids
Autore/i: PINI, ELENA RENATA ELVIRA
STRADI, RICCARDO
FALCHI, MARIO
Abstract: A new chemical named parrodienes has been extracted from parrots' plumage. From the chemical point of view, parrodienes are polyunsaturated aldehydes similar to carotenoids. On the basis of this similarity we organized some biological experiments to evaluate the inhibition of lipoperoxidation of cell membranes induced by CCl4, protection against ultraviolet rays, anti-inflammatory activity and protection from an increase of ornithine-decarboxylase as marker of tumoral skin alteration. The results of these experiments showed that unsaturated dienes (parrodienes) play an important role on the inhibition and prevention of many biological processes that are at the basis of different pathological disorders.
Data di pubblicazione: 2004
Citazione: Biological activity of parrodienes, a new class of polyunsaturated linear aldehydes similar to carotenoids / E. Pini, A. Bertelli, R. Stradi, M. Falchi. - In: Drugs under Experimental and Clinical Research. - ISSN 0378-6501. - 30:5-6(2004). - p. 203-206.
Evaluation of the antioxidant activity of new carotenoid-like compounds by electron paramagnetic resonance
Autore/i: STRADI, RICCARDO
FALCHI, MARIO
Abstract: The antioxidant activity of a novel series of derivatives with a carotenoid-like structure was studied. These derivatives have recently been isolated chemically as a result of studies on the pigments present in a particular species of birds, namely parrots. These novel derivatives, which are also called parrodienes, have been proved to possess interesting biological properties that differ from those that carotenoids are known to have. The objective of this study was to demonstrate the ability of these novel compounds to inhibit the formation of reactive oxygen species, especially their ability to block the formation of hydroxyl radicals, which are among the most reactive products of oxygen reactions and which produce the greatest damage to cells and tissues. The technique used to assess this antioxidant capacity of parrodienes was electron paramagnetic resonance, which allows direct assessment of inhibition of hydroxyl radical formation (.OH). The results show that these derivatives, especially octatriene, are able to exert evident antioxidant activity, thus confirming that their antioxidant properties are important for their biological activity.
Data di pubblicazione: 2003
Citazione: Evaluation of the antioxidant activity of new carotenoid-like compounds by electron paramagnetic resonance / R. Morelli, R. Loscalzo, R. Stradi , A. Bertelli, M. Falchi. - In: Drugs under Experimental and Clinical Research. - ISSN 0378-6501. - 29:3(2003). - p. 95-100.
Quindi non dovrebbe essere la GriseoFulvina...Per il resto...non trovo altro....bisogna indagare meglio [
)] spero sia utile..ciao
