Thymosin beta4 incrementa la crescita dei capelli!

S

sergio di rio

Utente
29 Ottobre 2003
62
0
65
Might be a broad-spectrum approach to treating specific forms of
alopecia. Looks like MMP-2 plays a role in anagen. Still - like
low-level laser therapy - it's not a method you want to mix with cancer
cells.

Rumor out of osteoscreen indicates that phase one clinical trials with
PSI were successful. While PSI is a potent cancer killer (blocking the
proteasome also blocks NFKB activation), PSI is probably not good for
neurodegnerative conditions like Parkinson's or Alzheimer's in which the
proteasome stops clearing out misfolded proteins. Whether or not PSI
crosses the blood-brain barrier or even gets into the blood from the
skin has not yet been determined.

FASEB J. 2004 Feb;18(2):385-7. Epub 2003 Dec 04. Related Articles, Links
Click here to read
Thymosin beta4 increases hair growth by activation of hair follicle
stem cells.

Philp D, Nguyen M, Scheremeta B, St-Surin S, Villa AM, Orgel A,
Kleinman HK, Elkin M.

Cell Biology Section, NIDCR, National Institutes of Health,
Bethesda, Maryland 20892, USA.

Thymosin beta4, a 43-amino acid polypeptide that is an important
mediator of cell migration and differentiation, also promotes
angiogenesis and wound healing. Here, we report that thymosin beta4
stimulates hair growth in normal rats and mice. A specific subset of
hair follicular keratinocytes in mouse skin expresses thymosin beta4 in
a highly coordinated manner during the hair growth cycle. These
keratinocytes originate in the hair follicle bulge region, a niche for
skin stem cells. Rat vibrissa follicle clonogenic keratinocytes, closely
related, if not identical, to the bulge-residing stem cells, were
isolated and their migration and differentiation increased in the
presence of nanomolar concentrations of thymosin beta4. Expression and
secretion of the extracellular matrix-degrading enzyme matrix
metalloproteinase-2 were increased by thymosin beta4. Thus, thymosin
beta4 accelerates hair growth, in part, due to its effect on critical
events in the active phase of the hair follicle cycle, including
promoting the migration of stem cells and their immediate progeny to the
base of the follicle, differentiation, and extracellular matrix
remodeling.

PMID: 14657002 [PubMed - in process]
[tp][cp]
 
S

sergio di rio

Utente
29 Ottobre 2003
62
0
65
Might be a broad-spectrum approach to treating specific forms of
alopecia. Looks like MMP-2 plays a role in anagen. Still - like
low-level laser therapy - it's not a method you want to mix with cancer
cells.

Rumor out of osteoscreen indicates that phase one clinical trials with
PSI were successful. While PSI is a potent cancer killer (blocking the
proteasome also blocks NFKB activation), PSI is probably not good for
neurodegnerative conditions like Parkinson's or Alzheimer's in which the
proteasome stops clearing out misfolded proteins. Whether or not PSI
crosses the blood-brain barrier or even gets into the blood from the
skin has not yet been determined.

FASEB J. 2004 Feb;18(2):385-7. Epub 2003 Dec 04. Related Articles, Links
Click here to read
Thymosin beta4 increases hair growth by activation of hair follicle
stem cells.

Philp D, Nguyen M, Scheremeta B, St-Surin S, Villa AM, Orgel A,
Kleinman HK, Elkin M.

Cell Biology Section, NIDCR, National Institutes of Health,
Bethesda, Maryland 20892, USA.

Thymosin beta4, a 43-amino acid polypeptide that is an important
mediator of cell migration and differentiation, also promotes
angiogenesis and wound healing. Here, we report that thymosin beta4
stimulates hair growth in normal rats and mice. A specific subset of
hair follicular keratinocytes in mouse skin expresses thymosin beta4 in
a highly coordinated manner during the hair growth cycle. These
keratinocytes originate in the hair follicle bulge region, a niche for
skin stem cells. Rat vibrissa follicle clonogenic keratinocytes, closely
related, if not identical, to the bulge-residing stem cells, were
isolated and their migration and differentiation increased in the
presence of nanomolar concentrations of thymosin beta4. Expression and
secretion of the extracellular matrix-degrading enzyme matrix
metalloproteinase-2 were increased by thymosin beta4. Thus, thymosin
beta4 accelerates hair growth, in part, due to its effect on critical
events in the active phase of the hair follicle cycle, including
promoting the migration of stem cells and their immediate progeny to the
base of the follicle, differentiation, and extracellular matrix
remodeling.

PMID: 14657002 [PubMed - in process]
[tp][cp]
 
S

sergio di rio

Utente
29 Ottobre 2003
62
0
65
Might be a broad-spectrum approach to treating specific forms of
alopecia. Looks like MMP-2 plays a role in anagen. Still - like
low-level laser therapy - it's not a method you want to mix with cancer
cells.

Rumor out of osteoscreen indicates that phase one clinical trials with
PSI were successful. While PSI is a potent cancer killer (blocking the
proteasome also blocks NFKB activation), PSI is probably not good for
neurodegnerative conditions like Parkinson's or Alzheimer's in which the
proteasome stops clearing out misfolded proteins. Whether or not PSI
crosses the blood-brain barrier or even gets into the blood from the
skin has not yet been determined.

FASEB J. 2004 Feb;18(2):385-7. Epub 2003 Dec 04. Related Articles, Links
Click here to read
Thymosin beta4 increases hair growth by activation of hair follicle
stem cells.

Philp D, Nguyen M, Scheremeta B, St-Surin S, Villa AM, Orgel A,
Kleinman HK, Elkin M.

Cell Biology Section, NIDCR, National Institutes of Health,
Bethesda, Maryland 20892, USA.

Thymosin beta4, a 43-amino acid polypeptide that is an important
mediator of cell migration and differentiation, also promotes
angiogenesis and wound healing. Here, we report that thymosin beta4
stimulates hair growth in normal rats and mice. A specific subset of
hair follicular keratinocytes in mouse skin expresses thymosin beta4 in
a highly coordinated manner during the hair growth cycle. These
keratinocytes originate in the hair follicle bulge region, a niche for
skin stem cells. Rat vibrissa follicle clonogenic keratinocytes, closely
related, if not identical, to the bulge-residing stem cells, were
isolated and their migration and differentiation increased in the
presence of nanomolar concentrations of thymosin beta4. Expression and
secretion of the extracellular matrix-degrading enzyme matrix
metalloproteinase-2 were increased by thymosin beta4. Thus, thymosin
beta4 accelerates hair growth, in part, due to its effect on critical
events in the active phase of the hair follicle cycle, including
promoting the migration of stem cells and their immediate progeny to the
base of the follicle, differentiation, and extracellular matrix
remodeling.

PMID: 14657002 [PubMed - in process]
[tp][cp]
 
F

freddi

Utente
7 Maggio 2003
75
0
65

Ci penso io
FREDDI



Ha potuto essere un metodo di vasto-spettro a trattare le forme specifiche dell'alopecia. Gli assomigli a MMP-2 svolge un ruolo in anagen. Ancora - come la terapia a basso livello del laser - non è un metodo che desideriate mescolare con le cellule di cancro. La voce da osteoscreen indica che le prove cliniche di fase una con lo PSI riuscivano. Mentre lo PSI è un assassino potente del cancro (ostruire il proteasome inoltre ostruisce l'attivazione di NFKB), lo PSI non è probabilmente buono per i termini neurodegnerative come Parkinson o Alzheimer in cui gli arresti proteasome che eliminano fuori misfolded le proteine. Se o non lo PSI attraversa la barriera ematomeningea o persino entra nell'anima dalla pelle ancora non è stato determinato. FASEB J. 2004 Feb;18(2):385-7. Dicembre 2003 Di Epub 04. Gli articoli relativi, collegamenti si scattano qui per leggere lo sviluppo dei capelli di aumenti di Thymosin beta4 dall'attivazione delle cellule formative del follicolo dei capelli. Philp D, Nguyen M., Scheremeta B, St-Surin S, Villa, Orgel A, Kleinman HK, Elkin M.. Sezione di biologia delle cellule, NIDCR, istituti nazionali di salute, Bethesda, Maryland 20892, S.U.A..
Thymosin beta4, un polipeptide acido 43-amino che è un mediatore importante di espansione e di differenziazione delle cellule, inoltre promuove il angiogenesis e la ferita che healing. Qui, segnaliamo che il thymosin beta4 stimola lo sviluppo dei capelli in ratti ed in mouse normali. Un sottoinsieme specifico dei keratinocytes follicular dei capelli nella pelle del mouse esprime il thymosin beta4 in un modo altamente coordinato durante il ciclo di sviluppo dei capelli. Questi keratinocytes provengono dalla regione del rigonfiamento del follicolo dei capelli, un posticino per le cellule formative della pelle. I keratinocytes clonogenic del follicolo del vibrissa del ratto, collegati strettamente, se non identico, alle cellule formative gonfi-risedenti, sono stati isolati e la loro espansione e differenziazione sono state aumentate in presenza delle concentrazioni nanomolar del thymosin beta4. L'espressione e la secrezione della tabella tabella-degradante extracellulare metalloproteinase-2 degli enzimi sono state aumentate dal thymosin beta4. Quindi, il thymosin beta4 accelera lo sviluppo dei capelli, in parte, dovuto il relativo effetto sugli eventi critici nella fase attiva del ciclo del follicolo dei capelli, compreso la promozione dell'espansione delle cellule forma
 
R

ronald

Utente
6 Maggio 2003
4,135
0
915
Citazione:Messaggio inserito da Mitzukunimito77
ne avevo parlato 3 mesi fa sergio....cmq tra poco ne sapremo di piu....grazie cmq per avere postate l articolo


adesso ne sai qualcosa? [^]
 
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