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J Ethnopharmacol. 2012 Feb 15;139(3):765-71. Epub 2011 Dec 13.
5á-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment.
Kumar N, Rungseevijitprapa W, Narkkhong NA, Suttajit M, Chaiyasut C.
Source
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Thailand.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE:
Many Thai traditional herbs have been used for hundreds of years for hair treatment and nourishment, including hair loss. However, scientific evidence about their mechanisms of action has not yet been elucidated.
AIMS OF THE STUDY:
The purpose of this research is to define the possible mechanisms involved in hair loss treatment of the selected plants by determining the 5á-reductase enzyme inhibition and hair growth promoting activities, and the relationship between these two activities.
MATERIALS AND METHODS:
Seventeen Thai plants traditionally used for hair treatment were selected. The plants were dried, ground and extracted by maceration with ethyl alcohol. These extracts were further tested for 5á-reductase inhibition using enzymes from rat livers. Hair growth promoting activity was tested in C57BL/6 mice.
RESULTS:
Carthamus tinctorius L. was the most potent 5á-reductase inhibitor, with a finasteride equivalent 5á-reductase inhibitory activity (FEA) value of 24.30±1.64mg finasteride equivalent per 1g crude extract. Phyllanthus emblica L. was the second most potent inhibitor, with FEA of 18.99±0.40. Rhinacanthus nasutus (L.) Kurz. was the least potent 5á-reductase inhibitor (FEA 10.69±0.96). Carthamus tinctorius also was the most potent hair growth promoter in C57BL/6 mice. There were strong relationships between 5á-reductase inhibitory activity and hair growth promoting activity (r=0.719), and between 5á-reductase inhibitory activity and hair follicle count (r=0.766).
CONCLUSIONS:
Ethanolic extract of Carthamus tinctorius was the most potent 5á-reductase inhibitor and hair growth promoter. This discovery may lead to the development of new alternative medicines for hair loss prevention and treatment.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
J Ethnopharmacol. 2012 Feb 15;139(3):765-71. Epub 2011 Dec 13.
5á-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment.
Kumar N, Rungseevijitprapa W, Narkkhong NA, Suttajit M, Chaiyasut C.
Source
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Thailand.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE:
Many Thai traditional herbs have been used for hundreds of years for hair treatment and nourishment, including hair loss. However, scientific evidence about their mechanisms of action has not yet been elucidated.
AIMS OF THE STUDY:
The purpose of this research is to define the possible mechanisms involved in hair loss treatment of the selected plants by determining the 5á-reductase enzyme inhibition and hair growth promoting activities, and the relationship between these two activities.
MATERIALS AND METHODS:
Seventeen Thai plants traditionally used for hair treatment were selected. The plants were dried, ground and extracted by maceration with ethyl alcohol. These extracts were further tested for 5á-reductase inhibition using enzymes from rat livers. Hair growth promoting activity was tested in C57BL/6 mice.
RESULTS:
Carthamus tinctorius L. was the most potent 5á-reductase inhibitor, with a finasteride equivalent 5á-reductase inhibitory activity (FEA) value of 24.30±1.64mg finasteride equivalent per 1g crude extract. Phyllanthus emblica L. was the second most potent inhibitor, with FEA of 18.99±0.40. Rhinacanthus nasutus (L.) Kurz. was the least potent 5á-reductase inhibitor (FEA 10.69±0.96). Carthamus tinctorius also was the most potent hair growth promoter in C57BL/6 mice. There were strong relationships between 5á-reductase inhibitory activity and hair growth promoting activity (r=0.719), and between 5á-reductase inhibitory activity and hair follicle count (r=0.766).
CONCLUSIONS:
Ethanolic extract of Carthamus tinctorius was the most potent 5á-reductase inhibitor and hair growth promoter. This discovery may lead to the development of new alternative medicines for hair loss prevention and treatment.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
