melatonina topica
- Thread starter lucotto8
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Caro lucotto
a giudicare dai risultati della sperimentazione con l'Asatex (lozione a base di melatonina) direi proprio che le apettative hanno superato la realtà dei fatti!
Ne consegue che personalmente ritengo che sia un buon coadiuvante sistemico in caso di problemi legati all'ansia ed alla mancanza di sonno che cmq possono influenzare negativamente sui capelli aumentando il livello di stress, ma che l'uso topico non costituisce una grande risorsa!
Un abbraccio
Cleopatra...[
]
a giudicare dai risultati della sperimentazione con l'Asatex (lozione a base di melatonina) direi proprio che le apettative hanno superato la realtà dei fatti!
Ne consegue che personalmente ritengo che sia un buon coadiuvante sistemico in caso di problemi legati all'ansia ed alla mancanza di sonno che cmq possono influenzare negativamente sui capelli aumentando il livello di stress, ma che l'uso topico non costituisce una grande risorsa!
Un abbraccio
Cleopatra...[
]
Eppure su pubmed ho trovato uno studio che conferma l'induzione dell'anagen quando si applica la melatonina topica!
Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial.
Fischer TW, Burmeister G, Schmidt HW, Elsner P.
Department of Dermatology and Allergology, Friedrich-Schiller-University, Erfurter Strasse 35, D-07740 Jena, Germany. tobias.fischer@derma.uni-jena.de
BACKGROUND: In addition to the well-known hormonal influences of testosterone and dihydrotestosterone on the hair cycle, melatonin has been reported to have a beneficial effect on hair growth in animals. The effect of melatonin on hair growth in humans has not been investigated so far. OBJECTIVES: To examine whether topically applied melatonin influences anagen and telogen hair rate in women with androgenetic or diffuse hair loss. METHODS: A double-blind, randomized, placebo-controlled study was conducted in 40 women suffering from diffuse alopecia or androgenetic alopecia. A 0.1% melatonin or a placebo solution was applied on the scalp once daily for 6 months and trichograms were performed to assess anagen and telogen hair rate. To monitor effects of treatment on physiological melatonin levels, blood samples were taken over the whole study period. RESULTS: Melatonin led to a significantly increased anagen hair rate in occipital hair in women with androgenetic hair loss compared with placebo (n=12; P=0.012). For frontal hair, melatonin gave a significant increase in the group with diffuse alopecia (n=28; P=0.046). The occipital hair samples of patients with diffuse alopecia and the frontal hair counts of those with androgenetic alopecia also showed an increase of anagen hair, but differences were not significant. Plasma melatonin levels increased under treatment with melatonin, but did not exceed the physiological night peak. CONCLUSIONS: To the authors' knowledge, this pilot study is the first to show that topically applied melatonin might influence hair growth in humans in vivo. The mode of action is not known, but the effect might result from an induction of anagen phase.
Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial.
Fischer TW, Burmeister G, Schmidt HW, Elsner P.
Department of Dermatology and Allergology, Friedrich-Schiller-University, Erfurter Strasse 35, D-07740 Jena, Germany. tobias.fischer@derma.uni-jena.de
BACKGROUND: In addition to the well-known hormonal influences of testosterone and dihydrotestosterone on the hair cycle, melatonin has been reported to have a beneficial effect on hair growth in animals. The effect of melatonin on hair growth in humans has not been investigated so far. OBJECTIVES: To examine whether topically applied melatonin influences anagen and telogen hair rate in women with androgenetic or diffuse hair loss. METHODS: A double-blind, randomized, placebo-controlled study was conducted in 40 women suffering from diffuse alopecia or androgenetic alopecia. A 0.1% melatonin or a placebo solution was applied on the scalp once daily for 6 months and trichograms were performed to assess anagen and telogen hair rate. To monitor effects of treatment on physiological melatonin levels, blood samples were taken over the whole study period. RESULTS: Melatonin led to a significantly increased anagen hair rate in occipital hair in women with androgenetic hair loss compared with placebo (n=12; P=0.012). For frontal hair, melatonin gave a significant increase in the group with diffuse alopecia (n=28; P=0.046). The occipital hair samples of patients with diffuse alopecia and the frontal hair counts of those with androgenetic alopecia also showed an increase of anagen hair, but differences were not significant. Plasma melatonin levels increased under treatment with melatonin, but did not exceed the physiological night peak. CONCLUSIONS: To the authors' knowledge, this pilot study is the first to show that topically applied melatonin might influence hair growth in humans in vivo. The mode of action is not known, but the effect might result from an induction of anagen phase.
Gli studi ci sono , l'efficacia effewttiva quando usata topicamente a mio modesto paree scarsa, almeno alle % dei preparati commerciali,in ogni caso per uso topico agisce da blando inibitore sterico dei recettori del dht.lo studio mostra solo un certo effetto sull'anagen non certo un efficacia clinicamente visibile.
saluti
saluti
Per uso sistemico e' un ottimo regolatore del ritmo sonnoveglia ,.indirettamente potrebbe essere utile se l'androgenetica e' peggiorata da incidenze.
saluti
saluti
grazie dottore, significa che per chi non ha problemi di sonno non ha ragione di essere utilizzata? ma il mio dubbio è, come in molti altri casi: perché mai qualcosa che da o dovrebbe dare effetti per via topica non dovrebbe farlo, a maggior ragione, anche se assunta per via sistemica?!
personalmente, in questo periodo di effluvio mi sono trovato benissimo ad aggiungere percentuali di asatex in un galenico a base di locoidon