Modulation of Hair Growth with Small Molecule Agonists
of the Hedgehog Signaling Pathway
The hedgehog (Hh) family of intercellular signaling proteins is intricately linked to the development and patterning
of almost every major vertebrate organ system. In the skin, sonic hedgehog (Shh) is required for hair follicle
morphogenesis during embryogenesis and for regulating follicular growth and cycling in the adult. We recently
described the identi#64257;cation and characterization of synthetic, non-peptidyl small molecule agonists of the Hh
pathway. In this study, we examined the ability of a topically applied Hh-agonist to modulate follicular cycling in
adult mouse skin. We report that the Hh-agonist can stimulate the transition from the resting (telogen) to the growth
(anagen) stage of the hair cycle in adult mouse skin. Hh-agonist-induced hair growth caused no detectable differences in epidermal proliferation, differentiation, or in the endogenous Hh-signaling pathway as measured by
Gli1, Shh, Ptc1, and Gli2 gene expression when compared with a normal hair cycle. In addition, we demonstrate that
Hh-agonist is active in human scalp in vitro as measured by Gli1 gene expression. These results suggest that the
topical application of Hh-agonist could be effective in treating conditions of decreased proliferation and aberrant
follicular cycling in the scalp including androgenetic alopecia (pattern hair loss).
http://www.hairlossfight.com/research/modulation_of_hair_growth_hedgehog.pdf
se ne dovrebbe essere già parlato da queste parti, credo, vero Marlin ?
of the Hedgehog Signaling Pathway
The hedgehog (Hh) family of intercellular signaling proteins is intricately linked to the development and patterning
of almost every major vertebrate organ system. In the skin, sonic hedgehog (Shh) is required for hair follicle
morphogenesis during embryogenesis and for regulating follicular growth and cycling in the adult. We recently
described the identi#64257;cation and characterization of synthetic, non-peptidyl small molecule agonists of the Hh
pathway. In this study, we examined the ability of a topically applied Hh-agonist to modulate follicular cycling in
adult mouse skin. We report that the Hh-agonist can stimulate the transition from the resting (telogen) to the growth
(anagen) stage of the hair cycle in adult mouse skin. Hh-agonist-induced hair growth caused no detectable differences in epidermal proliferation, differentiation, or in the endogenous Hh-signaling pathway as measured by
Gli1, Shh, Ptc1, and Gli2 gene expression when compared with a normal hair cycle. In addition, we demonstrate that
Hh-agonist is active in human scalp in vitro as measured by Gli1 gene expression. These results suggest that the
topical application of Hh-agonist could be effective in treating conditions of decreased proliferation and aberrant
follicular cycling in the scalp including androgenetic alopecia (pattern hair loss).
http://www.hairlossfight.com/research/modulation_of_hair_growth_hedgehog.pdf
se ne dovrebbe essere già parlato da queste parti, credo, vero Marlin ?
?