Facciamoci una cultura

sergio di rio

Utente
29 Ottobre 2003
62
0
65
Buona lettura!

Inhibitors of proteasomal activity for stimulating bone and hair growth

Abstract

The present invention relates to compounds that inhibit the activity of
the proteasome or the production of proteasomal proteins and promote
hair growth and the production of hair follicles and are thus useful in
stimulating hair growth, including hair density, in subject where this
is desirable.
Inventors: Mundy; Gregory R. (San Antonio, TX); Garrett; I. Ross (San
Antonio, TX); Rossini; Jorge Gianny (San Antonio, TX)
Assignee: OsteoScreen, Inc. (San Antonio, TX)
Appl. No.: 050633
Filed: January 15, 2002

Current U.S. Class: 514/2; 514/453; 514/880
Intern'l Class: A01N 037/18
Field of Search: 514/2,453,880
References Cited [Referenced By]
U.S. Patent Documents
4761471 Aug., 1988 Urist 530/350.
5280040 Jan., 1994 Labroo et al. 514/457.
5580854 Dec., 1996 Orlowski et al. 514/18.
5728844 Mar., 1998 Muller et al. 548/472.
5767152 Jun., 1998 Nielsen et al. 514/526.
5780454 Jul., 1998 Adams et al. 514/64.
5824643 Oct., 1998 Pierce et al. 514/12.
5910497 Jun., 1999 Durette et al. 514/253.
6083690 Jul., 2000 Harris et al. 435/6.
6147223 Nov., 2000 Fenteany et al. 548/453.
6410512 Jun., 2002 Mundy et al. 514/12.
Foreign Patent Documents
197 16 713 Oct., 1998 DE.
0 931 544 Jul., 1999 EP.
WO 90 11366 Oct., 1990 WO.
WO 92 03125 Mar., 1992 WO.
05 097697 Apr., 1993 WO.
WO 93 20859 Oct., 1993 WO.
WO 95 24211 Sep., 1995 WO.
WO 95 25533 Sep., 1995 WO.
WO 96 38590 Dec., 1996 WO.
WO 97 09315 Mar., 1997 WO.
WO 97 15308 May., 1997 WO.
WO 97 18239 May., 1997 WO.
WO 97 23457 Jul., 1997 WO.
WO 97 38699 Oct., 1997 WO.
WO 97 48694 Dec., 1997 WO.
WO 98 17267 Apr., 1998 WO.
WO 98 25460 Jun., 1998 WO.
WO 99 43346 Sep., 1999 WO.
WO 0002548 Jan., 2000 WO.


Other References

U.S. patent application Ser. No. 09/096,631.
Aub-Amer et al., NF-kB and Bone: The Breaking Point, Nature Medicine
(1997) 3(11):1189-1190.
Adams, J. et al., Proteasome Inhibitors: A Novel Class of Potent and
Effective Antitumor Agents, Cancer Res (1999) 59:2615-2622.
Adams et al., Chapter 28. Novel Inhibitors of the Proteasome and their
Therapeutic Use in Inflammation, Annual Reports in Medicinal Chemistry
(1996) 279-288.
Ahmed et al., Alopecia Universalis Associated with a Mutation in the
Human Hairless Gene, Science (1998) 279:720-724.
Bangham et al., Diffusion of Univalent Ions Across the Lamellae of
Swollen Phospholipids, J Mol
 

sergio di rio

Utente
29 Ottobre 2003
62
0
65
Buona lettura!

Inhibitors of proteasomal activity for stimulating bone and hair growth

Abstract

The present invention relates to compounds that inhibit the activity of
the proteasome or the production of proteasomal proteins and promote
hair growth and the production of hair follicles and are thus useful in
stimulating hair growth, including hair density, in subject where this
is desirable.
Inventors: Mundy; Gregory R. (San Antonio, TX); Garrett; I. Ross (San
Antonio, TX); Rossini; Jorge Gianny (San Antonio, TX)
Assignee: OsteoScreen, Inc. (San Antonio, TX)
Appl. No.: 050633
Filed: January 15, 2002

Current U.S. Class: 514/2; 514/453; 514/880
Intern'l Class: A01N 037/18
Field of Search: 514/2,453,880
References Cited [Referenced By]
U.S. Patent Documents
4761471 Aug., 1988 Urist 530/350.
5280040 Jan., 1994 Labroo et al. 514/457.
5580854 Dec., 1996 Orlowski et al. 514/18.
5728844 Mar., 1998 Muller et al. 548/472.
5767152 Jun., 1998 Nielsen et al. 514/526.
5780454 Jul., 1998 Adams et al. 514/64.
5824643 Oct., 1998 Pierce et al. 514/12.
5910497 Jun., 1999 Durette et al. 514/253.
6083690 Jul., 2000 Harris et al. 435/6.
6147223 Nov., 2000 Fenteany et al. 548/453.
6410512 Jun., 2002 Mundy et al. 514/12.
Foreign Patent Documents
197 16 713 Oct., 1998 DE.
0 931 544 Jul., 1999 EP.
WO 90 11366 Oct., 1990 WO.
WO 92 03125 Mar., 1992 WO.
05 097697 Apr., 1993 WO.
WO 93 20859 Oct., 1993 WO.
WO 95 24211 Sep., 1995 WO.
WO 95 25533 Sep., 1995 WO.
WO 96 38590 Dec., 1996 WO.
WO 97 09315 Mar., 1997 WO.
WO 97 15308 May., 1997 WO.
WO 97 18239 May., 1997 WO.
WO 97 23457 Jul., 1997 WO.
WO 97 38699 Oct., 1997 WO.
WO 97 48694 Dec., 1997 WO.
WO 98 17267 Apr., 1998 WO.
WO 98 25460 Jun., 1998 WO.
WO 99 43346 Sep., 1999 WO.
WO 0002548 Jan., 2000 WO.


Other References

U.S. patent application Ser. No. 09/096,631.
Aub-Amer et al., NF-kB and Bone: The Breaking Point, Nature Medicine
(1997) 3(11):1189-1190.
Adams, J. et al., Proteasome Inhibitors: A Novel Class of Potent and
Effective Antitumor Agents, Cancer Res (1999) 59:2615-2622.
Adams et al., Chapter 28. Novel Inhibitors of the Proteasome and their
Therapeutic Use in Inflammation, Annual Reports in Medicinal Chemistry
(1996) 279-288.
Ahmed et al., Alopecia Universalis Associated with a Mutation in the
Human Hairless Gene, Science (1998) 279:720-724.
Bangham et al., Diffusion of Univalent Ions Across the Lamellae of
Swollen Phospholipids, J Mol
 

sergio di rio

Utente
29 Ottobre 2003
62
0
65
Buona lettura!

Inhibitors of proteasomal activity for stimulating bone and hair growth

Abstract

The present invention relates to compounds that inhibit the activity of
the proteasome or the production of proteasomal proteins and promote
hair growth and the production of hair follicles and are thus useful in
stimulating hair growth, including hair density, in subject where this
is desirable.
Inventors: Mundy; Gregory R. (San Antonio, TX); Garrett; I. Ross (San
Antonio, TX); Rossini; Jorge Gianny (San Antonio, TX)
Assignee: OsteoScreen, Inc. (San Antonio, TX)
Appl. No.: 050633
Filed: January 15, 2002

Current U.S. Class: 514/2; 514/453; 514/880
Intern'l Class: A01N 037/18
Field of Search: 514/2,453,880
References Cited [Referenced By]
U.S. Patent Documents
4761471 Aug., 1988 Urist 530/350.
5280040 Jan., 1994 Labroo et al. 514/457.
5580854 Dec., 1996 Orlowski et al. 514/18.
5728844 Mar., 1998 Muller et al. 548/472.
5767152 Jun., 1998 Nielsen et al. 514/526.
5780454 Jul., 1998 Adams et al. 514/64.
5824643 Oct., 1998 Pierce et al. 514/12.
5910497 Jun., 1999 Durette et al. 514/253.
6083690 Jul., 2000 Harris et al. 435/6.
6147223 Nov., 2000 Fenteany et al. 548/453.
6410512 Jun., 2002 Mundy et al. 514/12.
Foreign Patent Documents
197 16 713 Oct., 1998 DE.
0 931 544 Jul., 1999 EP.
WO 90 11366 Oct., 1990 WO.
WO 92 03125 Mar., 1992 WO.
05 097697 Apr., 1993 WO.
WO 93 20859 Oct., 1993 WO.
WO 95 24211 Sep., 1995 WO.
WO 95 25533 Sep., 1995 WO.
WO 96 38590 Dec., 1996 WO.
WO 97 09315 Mar., 1997 WO.
WO 97 15308 May., 1997 WO.
WO 97 18239 May., 1997 WO.
WO 97 23457 Jul., 1997 WO.
WO 97 38699 Oct., 1997 WO.
WO 97 48694 Dec., 1997 WO.
WO 98 17267 Apr., 1998 WO.
WO 98 25460 Jun., 1998 WO.
WO 99 43346 Sep., 1999 WO.
WO 0002548 Jan., 2000 WO.


Other References

U.S. patent application Ser. No. 09/096,631.
Aub-Amer et al., NF-kB and Bone: The Breaking Point, Nature Medicine
(1997) 3(11):1189-1190.
Adams, J. et al., Proteasome Inhibitors: A Novel Class of Potent and
Effective Antitumor Agents, Cancer Res (1999) 59:2615-2622.
Adams et al., Chapter 28. Novel Inhibitors of the Proteasome and their
Therapeutic Use in Inflammation, Annual Reports in Medicinal Chemistry
(1996) 279-288.
Ahmed et al., Alopecia Universalis Associated with a Mutation in the
Human Hairless Gene, Science (1998) 279:720-724.
Bangham et al., Diffusion of Univalent Ions Across the Lamellae of
Swollen Phospholipids, J Mol
 

sasa

Utente
25 Luglio 2003
56
0
65
si parla del prodotto osteo,speriamo che i test vadano a buon fine nel piu breve tempo possibile