Lasciando da parte momentaneamente il mio presunto problema, informandomi qua e là ho trovato informazioni interessanti sulla modalità di assunzione delle compresse/pastiglie:
Methods
A prospective, open-label, 3-way crossover volunteer study at a tertiary university medical center with human subjects 18 years or older. Fasted subjects were randomly assigned to receive aspirin 1,950 mg as (1) solid aspirin tablets swallowed whole, (2) solid aspirin tablet chewed then swallowed, or (3) a chewable aspirin formulation chewed and swallowed. Serum salicylate measurements were obtained over a period of 180 minutes. Pharmacokinetic parameters were determined.
Results
Thirteen males and 1 female completed all 3 arms of study. Peak serum salicylate concentrations were seen at 180 minutes in all groups. Mean peaks were 10.4, 11.3, and 12.2 mg/dL in groups 1, 2, and 3, respectively. Mean area under the time concentration was 1,153, 1,401, and 1,743 mg-min/dL in groups 1, 2, and 3, respectively. No measurable salicylate concentrations were seen in 6 subjects in group 1 at 60 minutes as compared to 1 subject in group 2. All subjects in group 3 had measurable levels at 45 minutes. There were no adverse effects in any of the subjects during the study period.
In questo studio viene paragonata l'assunzione dell'aspirina come pastiglia orale inghiottita, come pastiglia orale masticata e inghiottita o come formulazione orale masticabile. La migliore è risultata quella formulata appositamente per la masticazione. Il Mean area under the time concentration rappresenta la quantità di farmaco in funzione del tempo e il mean peaks il picco massimo. La seconda migliore è stata quella nata per essere inghiottita ma che prima è stata masticata. Facendo due conti risulterebbe che la formulazione masticabile ha un efficacia del 150% di quella inghiottita e quella masticata da inghiottire del 120% di quella inghiottita.
Our data demonstrate that the chewable formulation of aspirin, as well as the chewing of solid tablets, increases the rate of absorption.
Aspirin absorption rates and platelet inhibition times with 325-mg buffered aspirin tablets (chewed or swallowed intact) and with buffered aspirin solution.
Feldman M, Cryer B.
Source
Dallas Department of Veterans Affairs Medical Center and Department of Internal Medicine, University of Texas Southwestern Medical School, 75216, USA. mark.feldman@med.va.gov
Abstract
Large clinical trials such as the second International Study of Infarct Survival routinely gave patients with myocardial infarction a chewed aspirin, yet there are no data to show whether chewing of aspirin is better, or worse, than swallowing a whole tablet. We performed a randomized, placebo-controlled study to determine whether chewing aspirin or administering it in solution accelerates its absorption and antiplatelet activity. On separate days, 12 fasting volunteers ingested 325 mg of buffered aspirin, either by chewing a tablet for 30 seconds before swallowing it with 4 ounces of water, swallowing a whole tablet with 4 ounces of water, or drinking 4 ounces of Alka Seltzer. Frequent blood samples were obtained for serum aspirin, salicylate, and thromboxane B2 (TxB2) concentrations. With all formulations of aspirin, serum TxB2 decreased 50% when the plasma aspirin concentration reached approximately 1,000 ng/ml. A 50% and 90% decrease in serum TxB2 occurred more quickly after chewing a tablet than after a tablet was swallowed whole. For example, the t 50% for serum TxB2 inhibition was 5.0 +/- 0.6 minutes with the chewed tablet versus 12.0 +/- 2.3 minutes when the tablet was swallowed (p = 0.01). A 50% decrease in serum TxB2 occurred 7.6 +/- 1.2 minutes after Alka Seltzer solution (p = 0.04 vs chewing a tablet; p = 0.13 vs swallowing a whole tablet). Chewing an aspirin tablet is the most effective way of accelerating absorption of aspirin into the blood and shortening the time required for an antiplatelet effect.
Questo è un altro studio precedente che conferma quanto detto.
E infine per chiudere l'argomento PROSCAR PROPECIA una volta per tutte
IL FILM SULLE COMPRESSE NON E GASTRORESISTENTE MA (E QUESTO é SCRITTO NEL BUGIARDINO) è SEMPLICEMENTE UNA PROTEZIONE PER EVITARE IL CONTATTO CON LE DONNE IN GRAVIDANZA (INFATTI RACCOMANDA DI EVITARE IL CONTATTO QUANDO LA COMPRESSA é FRANTUMATA).
Sui forum stranieri è stato discusso l'argomento e masticare o spezzettare il farmaco non ha causato la perdita di efficacia per nessuno che ha provato tale modalità (tutto al più si può sperare in un beneficio).
Spero di esser stato chiaro. Tra poco proverò a masticare la compressa
]