bhobho ha scritto:
un utente ha aggiornato con nuove foto ad un mese (dopo i 10 giorni di pausa). Come dicono sul forum è proprio difficile comparare il pre e il dopo perchè nelle foto precedenti al trattamento l'utente ha i capelli più lunghi e bagnati e le foto sono di scarsa qualità. Cmq, pistola alla tempia[
], direi che qualcosa si muove
ma parli di tyreze?
dalle foto non si evince molto
intanto il dibattito su hlh va avanti e spazia a 360°, c'è chi sostiene che non funzioni, chi che funzioni, chi dice che si creano nuovi follicoli, chi che vengono rigenerati i vecchi ecc
tyreze ora parla anche di fgf9, se ne era parlato qualche tempo fa con lo studio di cotsarelis
I read this on an other forum.
Fgf9 and wounding
According to Cotsarelis' team at the University of Pennsylvania, the reason that wounding does not regenerate enough hair follicles is that we do not have enough Fgf9 released when we are wounded. They also identified the responsible gd T Cells in our skin that produce this growth factor.
The Penn team suggests that, given the differences in skin development and regeneration in response to wounding, treatments intended to compensate for the lack of Fgf9 may be most effective if timed with a wounding response.
They also found out that the reason our wounds do not produce as much hair as mice is that we do not have enough Fgf9, which is crucial for the Wnt pathway.
When Fgf9 was reduced, there was a decrease in wound-induced hair follicle growth. Conversely, when Fgf9 was increased, there was a two- to three-fold increase in the number of new hair follicles, equal to the amount seen in the mice expressing Wnt.
So I believe that derma rolling = wounding is a working method, but it is not as fast as we expect due to our Fgf9 limitations (and other limitations that we do not know of). Hence, a possible experiment could include the Fgf9 growth factor in addition to derma rolling. I do not know where this leaves Minoxidil, but I would think that it's best to leave it out of the experiment and add it later if necessary.
Didn't someone say that Mr. Liuxuewu cure is releasing FGF9?
This could be also interesting:
http://www.uphs.upenn.edu/news...es/2013/06/cotsarelis/
Also see:
First time reading that laser ablation by itself increases FGF-9
In HUMAN skin.
Abstract
Fibroblast growth factor (FGF) 9 is secreted by both mesothelial and epithelial cells, and plays important roles in organ development and wound healing via WNT/?-catenin signaling. The aim of this study was to evaluate FGF9 expression and FGF-WNT/?-catenin signaling during wound healing of the skin. We investigated FGF9 expression and FGF-WNT/?-catenin signaling after laser ablation of mouse skin and adult human skin, as well as in cultured normal human epidermal keratinocytes (NHEKs) upon stimulation with recombinant human (rh) FGF9 and rh-transforming growth factor (TGF)-?1. Our results demonstrated that laser ablation of both mouse skin and human skin leads to marked overexpression of FGF9 and FGF9 mRNA. Control NHEKs constitutively expressed FGF9, WNT7b, WNT2, and ?-catenin, but did not show Snail or FGFR2 expression. We also found that FGF receptor (FGFR) 2 was significantly induced in NHEKs by rhFGF9 stimulation, and observed that FGFR2 expression was slightly upregulated on particular days during the wound healing process after ablative laser therapy. Both WNT7b and WNT2 showed upregulated protein expression during the laser-induced wound healing process in mouse skin; moreover, we discerned that the stimulatory effect of rhFGF9 and rhTGF-?1 activates WNT/?-catenin signaling via WNT7b in cultured NHEKs. Our data indicated that rhFGF9 and/or rhTGF-?1 upregulate FGFR2, WNT7b, and ?-catenin, but not FGF9 and Snail; pretreatment with rh dickkopf-1 significantly inhibited the upregulation of FGFR2, WNT7b, and ?-catenin. Our results suggested that FGF9 and FGF-WNT/?-catenin signaling may play important roles in ablative laser-induced wound healing processes
Source: http://www.ncbi.nlm.nih.gov/pubmed/25041895
copiato e incollato il post, il primo pezzo dice di averlo letto in un altro forum
