Antiossidanti, una bufala?

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18 Aprile 2009
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Prendere antiossidanti deve ancora dimostrare qualche beneficio.
Per esempio leggetevi questo: http://www.ncbi.nlm.nih.gov/pubmed/12114037
e questo: http://www.ncbi.nlm.nih.gov/pubmed/17327526
e questo:http://jama.ama-assn.org/cgi/content/abstract/300/18/2123
e questo: http://care.diabetesjournals.org/cgi/content/abstract/23/6/726
e questo: http://www.nature.com/ejcn/journal/v58/n10/abs/1601979a.html
e questo: http://www.cell.com/cell-metabolism/fulltext/S1550-4131%2809%2900257-5

Se poi fate attività sportiva, ancora peggio: Antioxidants prevent health-promoting effects of physical exercise in humans http://www.pnas.org/content/106/21/8665

e se siete diabetici o prediaberici: http://www.ncbi.nlm.nih.gov/pubmed/19693011

se volete vivere a lungo poi: Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7MFH-4PT7RDC-7&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4c63d173e513c789540c1c7bf97f2027

commento su hyperlipid blog:
Generally free radicals are considered to be a Bad Thing.

Actually, if you think about it, having your white blood cells throw free radicals at invading bacteria suggests that free radicals are one reason we are all still alive. Nothing is all bad.

So worms, under glucose restriction, generate far more free radicals than those able to access glucose.

Here's the best bit: The ones making all the free radicals also live longer. Don't forget, it's only a worm!

Why do they live longer? Because mitochondria can only work by using oxygen to run the respiratory chain. If using mitochondrial respiration was damaging, we wouldn't do it! It's POTENTIALLY damaging. Given the few billion years we've had, metabolism would have stopped this free radical production if it needed to. Evolution hasn't made the respiratory chain leak proof. Why? Free radical generation is the signal that mitochondrial respiration is happening and it's time to up regulate the cell's routine protection against free radical damage that has stood the test of time. This does not involve going off and eating some poor plant to steal its antioxidants.

Catalase, superoxide dismutase and glutathione peroxidase will do for a start. These are local antioxidant enzymes produced where they are needed, when they are needed by a cell whi