32nd Annual European Society for Dermatological Research (ESDR) Meeting 2002
September 19-21, 2002, Geneva, Switzerland
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Author: A. Ouchi
Abstract Number: 301
Abstract Title: T-Flavanone(t-FN), a Novel Hair Growth Promotor, Suppresses Hair Loss Through Reinforcing Hair Rooting
Author(s): E. Wakisaka, A. Ouchi, S. Moriwaki, T. Nomura, H. Kidena, M. Hotta and Y. Takema
Kao Co, Japan
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Abstract:
This study aims at investigating the mechanism of hair growth promoting activity of [T-Flavanone] t-FN(trans-3,4[prime]-dimethyl-3-hydroxyflavanone), a newly synthesized chemical derived from St John’s Wort. A double-blind usage test was performed on 84 healthy volunteers who had male pattern baldness. The subjects were divided into three groups with equal average baldness. At the beginning of the test, an evaluation area was set for each subject around the scalp where hair loss was prominent. Each group used, twice a day for six-months, a vasodilator-containing hair lotion supplemented either with 0% (control), 0.1%, or 0.3% t-FN. The efficacy of t-FN was evaluated in the set area, in terms of the total hair number, the terminal hair number, the percentage of terminal hairs, and the hair shaft diameter. At the end of the test period, the terminal hair tenacity was determined as an average peak force required for plucking out a single hair in a nonbald area, with a digital force gauge. In the six-month usage, the terminal hair number, a measure of growing-phase hair ratio, showed a tendency of t-FN dose-dependent increase. This increase was significant in the 0.3% group (p[thin space]=[thin space]0.02). The hair tenacity was also increased dose-dependently, being significant in the 0.3% group (p[thin space]=[thin space]0.03). This effect could be explained by stiff rooting of the hair in the scalp and/or by mere thickening of the hair shafts. Previously we had demonstrated that t-FN did increase hair shaft diameter. But, interestingly, even when hairs of the same diameter were compared, the tenacity was significantly increased in the 0.3% group (p[thin space]=[thin space]0.01). We speculate that t-FN may reinforce the hair rooting independent of the hair thickening. Taken together with our previous In vitro studies showing that t-FN enhances the cell adhesion molecule expression in hair follicles, th
September 19-21, 2002, Geneva, Switzerland
Meeting Home PageNew SearchAuthor Index
Search Criteria:
Author: A. Ouchi
Abstract Number: 301
Abstract Title: T-Flavanone(t-FN), a Novel Hair Growth Promotor, Suppresses Hair Loss Through Reinforcing Hair Rooting
Author(s): E. Wakisaka, A. Ouchi, S. Moriwaki, T. Nomura, H. Kidena, M. Hotta and Y. Takema
Kao Co, Japan
You can perform a Medline search by clicking on an author's name
Abstract:
This study aims at investigating the mechanism of hair growth promoting activity of [T-Flavanone] t-FN(trans-3,4[prime]-dimethyl-3-hydroxyflavanone), a newly synthesized chemical derived from St John’s Wort. A double-blind usage test was performed on 84 healthy volunteers who had male pattern baldness. The subjects were divided into three groups with equal average baldness. At the beginning of the test, an evaluation area was set for each subject around the scalp where hair loss was prominent. Each group used, twice a day for six-months, a vasodilator-containing hair lotion supplemented either with 0% (control), 0.1%, or 0.3% t-FN. The efficacy of t-FN was evaluated in the set area, in terms of the total hair number, the terminal hair number, the percentage of terminal hairs, and the hair shaft diameter. At the end of the test period, the terminal hair tenacity was determined as an average peak force required for plucking out a single hair in a nonbald area, with a digital force gauge. In the six-month usage, the terminal hair number, a measure of growing-phase hair ratio, showed a tendency of t-FN dose-dependent increase. This increase was significant in the 0.3% group (p[thin space]=[thin space]0.02). The hair tenacity was also increased dose-dependently, being significant in the 0.3% group (p[thin space]=[thin space]0.03). This effect could be explained by stiff rooting of the hair in the scalp and/or by mere thickening of the hair shafts. Previously we had demonstrated that t-FN did increase hair shaft diameter. But, interestingly, even when hairs of the same diameter were compared, the tenacity was significantly increased in the 0.3% group (p[thin space]=[thin space]0.01). We speculate that t-FN may reinforce the hair rooting independent of the hair thickening. Taken together with our previous In vitro studies showing that t-FN enhances the cell adhesion molecule expression in hair follicles, th