Birth Defects Res Part A Clin Mol Teratol. 2003 Dec; 67(12): 997-1001.
Topically applied minoxidil may cause fetal malformation: A case report.
Smorlesi C, Caldarella A, Caramelli L, Di Lollo S, Moroni F.
Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze
and Azienda Ospedaliera Careggi, Firenze, Italy.
BACKGROUND: Minoxidil is a K(+) channel opener able to cause relaxation
of vascular smooth muscles and modify cell growth and cell fate or
migration. It is now widely used for its hair growth promoting effects.
When locally applied, it is absorbed through the skin and may have
systemic pharmacological effects. CASE: A 28-year-old white pregnant
woman daily applied minoxidil 2% to her scalp because of hair loss. At
the 22nd gestational week, after a routine ultrasound test showing
significant brain, heart, and vascular malformations of the fetus,
pregnancy was interrupted. The placenta had numerous ischemic areas and
a discrepancy between gestational age and villi maturation. In the
villi, capillaries were increased in number, significantly enlarged, and
excessively marginalized. The fetus' heart was increased in volume and
had a globose shape, the aorta had a distal stenosis. The sigmoid colon
was significantly increased in length and a mesentery commune was
present. The brain had enlarged ventricles and abundant hemorrhages.
Histological examination showed areas of demyelinization with gliosis,
signs of excessive and inappropriate angiogenesis, and capillary
rearrangement. CONCLUSIONS: Further knowledge on minoxidil-induced fetal
toxicity would be beneficial before allowing its use in pregnant women.
Birth Defects Research (Part A), 2003. Copyright 2003 Wiley-Liss, Inc.
PMID: 14745922
Se volete tradurlo...
ciao[cp][cc]
Topically applied minoxidil may cause fetal malformation: A case report.
Smorlesi C, Caldarella A, Caramelli L, Di Lollo S, Moroni F.
Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze
and Azienda Ospedaliera Careggi, Firenze, Italy.
BACKGROUND: Minoxidil is a K(+) channel opener able to cause relaxation
of vascular smooth muscles and modify cell growth and cell fate or
migration. It is now widely used for its hair growth promoting effects.
When locally applied, it is absorbed through the skin and may have
systemic pharmacological effects. CASE: A 28-year-old white pregnant
woman daily applied minoxidil 2% to her scalp because of hair loss. At
the 22nd gestational week, after a routine ultrasound test showing
significant brain, heart, and vascular malformations of the fetus,
pregnancy was interrupted. The placenta had numerous ischemic areas and
a discrepancy between gestational age and villi maturation. In the
villi, capillaries were increased in number, significantly enlarged, and
excessively marginalized. The fetus' heart was increased in volume and
had a globose shape, the aorta had a distal stenosis. The sigmoid colon
was significantly increased in length and a mesentery commune was
present. The brain had enlarged ventricles and abundant hemorrhages.
Histological examination showed areas of demyelinization with gliosis,
signs of excessive and inappropriate angiogenesis, and capillary
rearrangement. CONCLUSIONS: Further knowledge on minoxidil-induced fetal
toxicity would be beneficial before allowing its use in pregnant women.
Birth Defects Research (Part A), 2003. Copyright 2003 Wiley-Liss, Inc.
PMID: 14745922
Se volete tradurlo...
ciao[cp][cc]
