Background/Aim: Telogen effluvium (TE) is a scalp disorder characterized by the thinning or shedding of hair result-ing from the early entry of hair in the telogen phase. Nigella sativa (NS) is a dicotyledonous belonging to the Ranuncu-lacae family. It has been shown that its major constituent, tymoquinon (TQ), exerts anti-oxidant and anti-inflammatory effects by inhibiting pro-inflammatory mediators, such as cyclooxygenase and prostaglandin D2. The aim of this study is to evaluate the efficacy of NS essential oil as a potential treatment for TE, a pathology characterized by a significant inflammatory component. Study Design/Methods: Twenty patients affected by TE for this double-blind, placebo con- trolled and randomized study were enrolled. Ten of these patients were treated with a scalp lotion containing 0.5% NS, daily for 3 months, while the other ten patients were treated with placebo daily for 3 months. Videodermatoscopic analysis (Trichoscan Dermoscope Fotofinder®) and evaluation of three independent dermatologists were performed before treatment (T0), after 3 months of treatment (T3) and at the 6 months follow-up (T6). Results: The results showed a significant improvement in 70% of patients treated with NS. Videodermatoscopic analysis showed a signifi- cant increment of hair density and hair thickness in patients treated with NS. NS was also able to reduce the inflamma- tion observed in the majority of patients affected by TE. Conclusions: The results of this study suggest that NS can be considered potentially useful for the treatment of TE.
Keywords: Telogen Effluvium; Nigella sativa; Hair Density; Hair Thicknes
sembra basti lo 0.5% di nigella,non parla del principio timochinone..sappiamo quanto ne contiene il regladin? magari essendo costosa ne contiene un piccola percentuale...sopratutto quanto poi aggiungono altri ingredienti......