mi domandavo quale sia il meccanismo che attivi la ginecomastia
allora ho trovato questo testo
http://books.google.com/books?id=FVfzRva...http://books.google.com/books?id=FVfzRvaucq8C&lpg=PA1203&ots=xZhRr__8ZT&dq=gynecomastia%20%20androgen%20receptor&pg=PA1195#v=onepage
qui parla di antiandrogeni e dice
Citazione:Other drugs may produce gynecomastia by interfering with androgen production or action ,thus increasing the estrogen/androgen ratio effect at the breast. The antifungal agent ketoconazole is a potent inhibitor of testosterone biosynthesis and can cause gynecomastia.However ,because of its pharmacokinetics,the incidence of gynecomastia is low when the drug is given in a once-a-dy dosage this regimen allows the serum testosterone levels to normalize before each succeding dose.Traditional antiandrogens (cyproterone,flutamide).as well as the H2-blocker cimetidine,appear to cause gynecomastia by blocking androgen receptor at the breast rather than by decresing androgen production; they cause an increased effective estrogen/androgen ratio in the breast tissue.This side effect of cimetidine is most common when high doses are used to treat Zollinger_ellison syndrome and is seen much less frequently with other antiulceral drugs,such as rantidine or omeprazole.The blockade of androgen action at the breast by a commercial insecticide has been implicated in an epidemic of gynecomastia in Haitian immigrants.The aldosterone antagonist spironolactone ,frequetly used as a diuretic ,may block androgen receptor as well as interfere with androgen production,thereby leading to an increased effective estrogen/adnrogen ratio at the breast.here ,too,the breast enlargement is seen most commonly at high dosages,as in the treatment of primary hyperaldosteronism.Finasteride ,wich is used in the treatment of prostate disorders and which inhibits 5-a- reductase and reduces intracellular levels of active androgen (dihydrosterone) in targets issues,has also been associated with gynecomastia.
A wide variety of neurotransmitter agonists,antagonists,or modulators that are used to treat hypertension or pshychiatric disorders have been associated with gynecomastia,but the nature and mechanism of this connection are largely unexplored.Also ,such agents commonly are associated with hyperprolactinemia,which may cause secondary hypogonadism.
An increasingly frequent cause of drug-related gynecomastia is cancer chemotherapeutic agents.Gyne
allora ho trovato questo testo
http://books.google.com/books?id=FVfzRva...http://books.google.com/books?id=FVfzRvaucq8C&lpg=PA1203&ots=xZhRr__8ZT&dq=gynecomastia%20%20androgen%20receptor&pg=PA1195#v=onepage
qui parla di antiandrogeni e dice
Citazione:Other drugs may produce gynecomastia by interfering with androgen production or action ,thus increasing the estrogen/androgen ratio effect at the breast. The antifungal agent ketoconazole is a potent inhibitor of testosterone biosynthesis and can cause gynecomastia.However ,because of its pharmacokinetics,the incidence of gynecomastia is low when the drug is given in a once-a-dy dosage this regimen allows the serum testosterone levels to normalize before each succeding dose.Traditional antiandrogens (cyproterone,flutamide).as well as the H2-blocker cimetidine,appear to cause gynecomastia by blocking androgen receptor at the breast rather than by decresing androgen production; they cause an increased effective estrogen/androgen ratio in the breast tissue.This side effect of cimetidine is most common when high doses are used to treat Zollinger_ellison syndrome and is seen much less frequently with other antiulceral drugs,such as rantidine or omeprazole.The blockade of androgen action at the breast by a commercial insecticide has been implicated in an epidemic of gynecomastia in Haitian immigrants.The aldosterone antagonist spironolactone ,frequetly used as a diuretic ,may block androgen receptor as well as interfere with androgen production,thereby leading to an increased effective estrogen/adnrogen ratio at the breast.here ,too,the breast enlargement is seen most commonly at high dosages,as in the treatment of primary hyperaldosteronism.Finasteride ,wich is used in the treatment of prostate disorders and which inhibits 5-a- reductase and reduces intracellular levels of active androgen (dihydrosterone) in targets issues,has also been associated with gynecomastia.
A wide variety of neurotransmitter agonists,antagonists,or modulators that are used to treat hypertension or pshychiatric disorders have been associated with gynecomastia,but the nature and mechanism of this connection are largely unexplored.Also ,such agents commonly are associated with hyperprolactinemia,which may cause secondary hypogonadism.
An increasingly frequent cause of drug-related gynecomastia is cancer chemotherapeutic agents.Gyne
