Dutasteride (Advodart) versus Finasteride (Propecia)
Virtually anyone who has researched hair loss treatments is familiar with Propecia (active ingredient Finasteride). This once a day pill, which inhibits the formation of the hair loss catalyst DHT in the body and thus scalp, is FDA approved as a hair loss treatment and widely known to be effective.
However, some hair loss sufferers have sought and gotten prescriptions for an even stronger DHT inhibiting drug known as Dutasteride (marketed as Avodart). This drug, like Finasteride, is FDA approved for the treatment of benign prostatic hypertrophy (enlarged prostrate). However, Dutasteride (Avodart), unlike Propecia (Finasteride), has not been FDA approved as a hair loss treatment.
Despite not being FDA approved as a hair loss treatment some physicians do prescribe it as a hair loss treatment, often only if Propecia fails to stop hair loss for a particular patient.
Both finasteride and dutasteride inhibit the development of the type 2 alpha reductase that plays a critical role in the creation of the hair loss causing hormone DHT, only dutasteride also effectively inhibits the development of the type 1 alpha reductase that also plays a role in creating DHT.
According to Dr. Bernie Nusbaum, who presented an update on Dutasteride therapy at the meeting, dutasteride is three times more potent than finateride at inhibiting the type 2 enzyme and 300 times more potent than finasteride in inhibiting the type 1 enzyme.
Based on a randomized, placebo controlled study of 416 male hair loss sufferers, dutasteride improved hair growth in these men more rapidly and to a greater degree than finasteride.
However, dutasteride was shown to remain in the body far longer than finasteride after being discontinued. Dutasteride was also found to reduce sperm counts more dramatically than finasteride along with a higher incidence of decreased libido (13%).
Of additional concern, dutasteride, unlike finasteride, reduces the type 1 enzyme which is found in the brain – unlike the type 2 enzyme which is not present in the brain. Apparently it is not clear at this time what role the type 1 enzyme may or may not play in the functioning of the brain. Thus dutasteride could potentially have yet unknown side effects due to reducing the type 2 enzyme in the brain.
Tramite traduttore simultaneo vi riporto le parti più importanti:
Sia dalla finasteride e dutasteride inibire lo sviluppo di tipo 2 alfa ridutta
Virtually anyone who has researched hair loss treatments is familiar with Propecia (active ingredient Finasteride). This once a day pill, which inhibits the formation of the hair loss catalyst DHT in the body and thus scalp, is FDA approved as a hair loss treatment and widely known to be effective.
However, some hair loss sufferers have sought and gotten prescriptions for an even stronger DHT inhibiting drug known as Dutasteride (marketed as Avodart). This drug, like Finasteride, is FDA approved for the treatment of benign prostatic hypertrophy (enlarged prostrate). However, Dutasteride (Avodart), unlike Propecia (Finasteride), has not been FDA approved as a hair loss treatment.
Despite not being FDA approved as a hair loss treatment some physicians do prescribe it as a hair loss treatment, often only if Propecia fails to stop hair loss for a particular patient.
Both finasteride and dutasteride inhibit the development of the type 2 alpha reductase that plays a critical role in the creation of the hair loss causing hormone DHT, only dutasteride also effectively inhibits the development of the type 1 alpha reductase that also plays a role in creating DHT.
According to Dr. Bernie Nusbaum, who presented an update on Dutasteride therapy at the meeting, dutasteride is three times more potent than finateride at inhibiting the type 2 enzyme and 300 times more potent than finasteride in inhibiting the type 1 enzyme.
Based on a randomized, placebo controlled study of 416 male hair loss sufferers, dutasteride improved hair growth in these men more rapidly and to a greater degree than finasteride.
However, dutasteride was shown to remain in the body far longer than finasteride after being discontinued. Dutasteride was also found to reduce sperm counts more dramatically than finasteride along with a higher incidence of decreased libido (13%).
Of additional concern, dutasteride, unlike finasteride, reduces the type 1 enzyme which is found in the brain – unlike the type 2 enzyme which is not present in the brain. Apparently it is not clear at this time what role the type 1 enzyme may or may not play in the functioning of the brain. Thus dutasteride could potentially have yet unknown side effects due to reducing the type 2 enzyme in the brain.
Tramite traduttore simultaneo vi riporto le parti più importanti:
Sia dalla finasteride e dutasteride inibire lo sviluppo di tipo 2 alfa ridutta
