Messaggio inserito da capelluto
Vorrei sapere se allo stato attuale qualcuno sa indicarmi una ricetta per un galenico contenente acido fosfatidico.
Rendiamo disponibile l' abstract della pubblicazione riguardante gli studi comparativi in vitro e in vivo dell' attività di diversi acidi fosfatidici paragonati a quella del minoxidil.
Stiamo mettendo a punto una preparazione idroalcolica di questo fosfolipide che, come leggerete, promette risultati tangibili e forse sarà di grande aiuto a chi è ancora restìo ad assumere preparati farmacologici a base di minoxidil e/o derivati steroidici.L'esperimento pubblicato su una rivista qualificata descrive risultati veramente interessanti e apre sicuramente nuove prospettive.
Su richiesta rendiamo disponibile l'articolo originale in estenso
Phosphatidic acid has a potential to promote hair growth in
vitro and in vivo, and activates mitogen-activated protein
kinase/extracellular signal-regulated kinase kinase in hair
epithelial cells.
Phospholipids have recently been discovered to play an important
role in cellular regulation. In this study, we focused on
phosphatidic acid and lysophosphatidic acid, which are phospholipids
known to possess growth-hormonal effects on several types of cells,
and examined their growth-promoting effects on murine hair
epithelial cells. We discovered that phosphatidic acid possesses
intensive growth-promotional effects on hair epithelial cells and
epidermal keratinocytes. In contrast, lyso-phosphatidic acid showed
lower growth-promoting effects on hair epithelial cells relative to
phosphatidic acid and showed minimal or no growth-promoting activity
on epidermal keratinocytes. Phosphatidic acid was also shown to have
hair-growing activity to induce the anagen phase of the hair cycle
in the in vivo murine model. For the purpose of examining the
hair-growing mechanisms of phosphatidic acid, we examined its
relationship to the mitogen-activated protein kinase cascade linked
to cell proliferation and the transforming growth factor beta signal
pathway known to be a regulator of catagen induction. We confirmed
that phosphatidic acid activates MEK-1/2 and upregulates the
expression of MEK-1/2 in cultured murine hair epithelial cells.
Addition of transforming growth factor beta1 to hair epithelial cell
cultures concentration-dependently decreased cell growth and induced
apoptosis; however, addition of phosphatidic acid to the culture
neutralized the growth-inhibiting effects of transforming growth
factor beta1 and protected the cells from apoptosis. We speculate
that the hair-growing activity of phosphatidic acid is at least
linked to its growth-promoting effects on hair epithelial cells that
follow mitogen-activated protein kinase/extracellular
signal-regulated kinase kinase activation and its protective action
on transforming-growth-factor-beta1-induced apoptosis that is
assumed to trigger catagen induction in the hair cycle.
PMID: 12925199 [PubMed - indexed for MEDLINE]
