ACIDO FOSFATIDICO cosa serve esattamente
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Citazione:Messaggio inserito da fabio84
ma c'è un post apposito, perche ne apri un altro... è in fase di sperimentazione, i primi risultati sono confortanti, ma non si sa bene... leggi il post relativo... aspettiamo notizie certe dai guru. Bye
hahahahha mittico!!! [^]
ma c'è un post apposito, perche ne apri un altro... è in fase di sperimentazione, i primi risultati sono confortanti, ma non si sa bene... leggi il post relativo... aspettiamo notizie certe dai guru. Bye
hahahahha mittico!!! [^]
Citazione:Messaggio inserito da capelluto
Quanto si dovrà attendere per le notizie certe dai guru?[
]
quello che per ora si sa è racchiuso fra queste pagine. Se non avete problemi con l'inglese potete leggerle http://www.nature.com/jid/journal/v121/n3/pdf/5601911a.pdf
Numerous researchers have investigated scientifically proven hair growth stimulants with respect to the mechanisms of action of how they exert hair-growing activity. One of these compounds,
minoxidil (Rogaines, Upjohn, Kalamazoo, MI), originally synthesized as a potassium channel opener (Buhl et al, 1993) and initially prescribed for hypertension, is an FDA-approved topical medication for treating male pattern baldness (Kulick, 1988; Olsen, 1989). Minoxidil is known to possess growthpromoting effects on hair epithelial cells (Tanigaki-Obana and Ito, 1992) and stimulates anagen induction of the hair cycle in animal models (Uno et al, 1985). The mechanisms of action by which minoxidil stimulates hair growth have not been fully elucidated; growth-factor-related mechanisms (Xxxxxx et al, 1996; Lachgar et al, 1998; Yamazaki et al, 1999) and the e¡ects of increased blood circulation in the capillary vessels (Hirkaler and Rosenberger, 1989) have been proposed. Cyclosporin A is a potent immunosuppressant, known to possess hair-growing activity by stimulating anagen induction in animal models (Paus et al, 1989), and which causes hirsutism in humans (Wysocki and Daley, 1987); it has been shown to possess growth-promoting effects on hair epithelial cells in vitro (Takahashi and Kamimura, 2001).We have recently found hair epithelial cell growth-promoting activity in proanthocyanidins such as procyanidin B-2, procyanidin B-3, and procyanidin C-1 (Takahashi et al, 1999; Kamimura and Takahashi, 2002) and have illustrated that these compounds have the potential to induce the anagen phase of the
hair cycle in the in vivo murine model. In androgenetic alopecia, drugs targeting steroid receptors, steroid-metabolizing enzymes, growth factors, and cytokines have been investigated as potential agents for curing or treating this condition; hair follicular activation, such as hair epithelial cell growth promotion, may be an important index for evaluating the efficacy of hair growth stimulants (Shapiro and Price, 1998).
Concerns about biologically active phospholipids are attracting the interest of a growing number of researchers. Lysophosphatidic acid and phosphatidic acid are of particular interest. These two substances have been shown to exert growth-hormonal effects on numerous types of cells and to produce a range of cellular responses in which receptor and nonreceptor-mediated mechanisms have been implicated (Nietgen and Durieux, 1998; Steed and Chow, 2001). Phosphatidic acid also has been identi¢ed as a second messenger (Liscovitch and Cantley, 1994; McPhail et al, 1999). Phosphatidic acid is reported to promote growth of many types of cells, including mouse-embryo-derived ¢broblast-like C3H/10T1/2 cells (Krabak and Hui, 1991), mouse-embryo-derived ¢broblast-like Swiss 3T3 cells (Wood et al, 1993), rat ¢broblast cell line Rat-1, human ¢broblasts (van Corven et al, 1992), caninekidney-derived epithelial-like MDCK cells (Bashir et al, 1992), human epidermoid carcinoma A431 cells (Kaszkin et al, 1992), endothelial cells (English et al, 2001), mesangial cells (Kester et al, 1989; Kester, 1993), cortical astrocyte cells (Pearce et al, 1994), and osteoblastic cells (Carpio and Dziak, 1998). Phosphatidic acid has also been shown to play an important role in controlling cell division through being involved in the mechanisms of G1 to S transition (Flores et al, 1999).
On the other hand, lysophosphatidic acid has also been shown to promote the growth of many types of cells (Moolenaar, 1995): e.g., it has been reported to have growth-promoting activity on endothelial cells (Panetti et al, 1997; Lee et al, 2000a), smooth muscle cells (Cerutis et al, 1997), B lymphoblasts (Rosskopf et al, 1998), and ¢broblasts (van Corven et al, 1989; 1992). This paper describes our investigation of the effects of phosphatidic acid and lysophosphatidic acid on murine hair epithelial cells and epidermal keratinocytes. We examined the efficacy of these agents with respect to murine hair growth; and, for the first time, found that phosphatidic acid intensively promotes hair epithelial cell growth and stimulates anagen induction in the hair cycle progression in vivo. We also examined the mechanisms of action of the hair-growing activity stimulated by phosphatidic acid, focusing on its relation to activation of the mitogen-activated protein kinase cascade and transforming growth factor b1 (TGF-b1) induced cellular responses in hair epithelial cells, i.e., apoptotic cell death (Schuster and Krieglstein, 2002). We speculate that the hair-growing activity of phosphatidic acid is at least linked to its growth-promoting effects on hair epithelial cells sequential to mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)activation and its protective action on TGF-b1-induced apoptotic cell death that is assumed to trigger catagen induction (Seiberg et al, 1995; Foitzik et al, 2000) in the hair cycle.
Quanto si dovrà attendere per le notizie certe dai guru?[
]quello che per ora si sa è racchiuso fra queste pagine. Se non avete problemi con l'inglese potete leggerle http://www.nature.com/jid/journal/v121/n3/pdf/5601911a.pdf
Numerous researchers have investigated scientifically proven hair growth stimulants with respect to the mechanisms of action of how they exert hair-growing activity. One of these compounds,
minoxidil (Rogaines, Upjohn, Kalamazoo, MI), originally synthesized as a potassium channel opener (Buhl et al, 1993) and initially prescribed for hypertension, is an FDA-approved topical medication for treating male pattern baldness (Kulick, 1988; Olsen, 1989). Minoxidil is known to possess growthpromoting effects on hair epithelial cells (Tanigaki-Obana and Ito, 1992) and stimulates anagen induction of the hair cycle in animal models (Uno et al, 1985). The mechanisms of action by which minoxidil stimulates hair growth have not been fully elucidated; growth-factor-related mechanisms (Xxxxxx et al, 1996; Lachgar et al, 1998; Yamazaki et al, 1999) and the e¡ects of increased blood circulation in the capillary vessels (Hirkaler and Rosenberger, 1989) have been proposed. Cyclosporin A is a potent immunosuppressant, known to possess hair-growing activity by stimulating anagen induction in animal models (Paus et al, 1989), and which causes hirsutism in humans (Wysocki and Daley, 1987); it has been shown to possess growth-promoting effects on hair epithelial cells in vitro (Takahashi and Kamimura, 2001).We have recently found hair epithelial cell growth-promoting activity in proanthocyanidins such as procyanidin B-2, procyanidin B-3, and procyanidin C-1 (Takahashi et al, 1999; Kamimura and Takahashi, 2002) and have illustrated that these compounds have the potential to induce the anagen phase of the
hair cycle in the in vivo murine model. In androgenetic alopecia, drugs targeting steroid receptors, steroid-metabolizing enzymes, growth factors, and cytokines have been investigated as potential agents for curing or treating this condition; hair follicular activation, such as hair epithelial cell growth promotion, may be an important index for evaluating the efficacy of hair growth stimulants (Shapiro and Price, 1998).
Concerns about biologically active phospholipids are attracting the interest of a growing number of researchers. Lysophosphatidic acid and phosphatidic acid are of particular interest. These two substances have been shown to exert growth-hormonal effects on numerous types of cells and to produce a range of cellular responses in which receptor and nonreceptor-mediated mechanisms have been implicated (Nietgen and Durieux, 1998; Steed and Chow, 2001). Phosphatidic acid also has been identi¢ed as a second messenger (Liscovitch and Cantley, 1994; McPhail et al, 1999). Phosphatidic acid is reported to promote growth of many types of cells, including mouse-embryo-derived ¢broblast-like C3H/10T1/2 cells (Krabak and Hui, 1991), mouse-embryo-derived ¢broblast-like Swiss 3T3 cells (Wood et al, 1993), rat ¢broblast cell line Rat-1, human ¢broblasts (van Corven et al, 1992), caninekidney-derived epithelial-like MDCK cells (Bashir et al, 1992), human epidermoid carcinoma A431 cells (Kaszkin et al, 1992), endothelial cells (English et al, 2001), mesangial cells (Kester et al, 1989; Kester, 1993), cortical astrocyte cells (Pearce et al, 1994), and osteoblastic cells (Carpio and Dziak, 1998). Phosphatidic acid has also been shown to play an important role in controlling cell division through being involved in the mechanisms of G1 to S transition (Flores et al, 1999).
On the other hand, lysophosphatidic acid has also been shown to promote the growth of many types of cells (Moolenaar, 1995): e.g., it has been reported to have growth-promoting activity on endothelial cells (Panetti et al, 1997; Lee et al, 2000a), smooth muscle cells (Cerutis et al, 1997), B lymphoblasts (Rosskopf et al, 1998), and ¢broblasts (van Corven et al, 1989; 1992). This paper describes our investigation of the effects of phosphatidic acid and lysophosphatidic acid on murine hair epithelial cells and epidermal keratinocytes. We examined the efficacy of these agents with respect to murine hair growth; and, for the first time, found that phosphatidic acid intensively promotes hair epithelial cell growth and stimulates anagen induction in the hair cycle progression in vivo. We also examined the mechanisms of action of the hair-growing activity stimulated by phosphatidic acid, focusing on its relation to activation of the mitogen-activated protein kinase cascade and transforming growth factor b1 (TGF-b1) induced cellular responses in hair epithelial cells, i.e., apoptotic cell death (Schuster and Krieglstein, 2002). We speculate that the hair-growing activity of phosphatidic acid is at least linked to its growth-promoting effects on hair epithelial cells sequential to mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK)activation and its protective action on TGF-b1-induced apoptotic cell death that is assumed to trigger catagen induction (Seiberg et al, 1995; Foitzik et al, 2000) in the hair cycle.
E' una sostanza che per uso topico ha un alto profilo di sicurezza, sicuramente molto più sicura del minox e degli estrogeni topici: e in più è un fosfoplipide naturale, che viene estratto dall'uovo
il mio prodotto preferito e' la Bentley continental gt , ma per curarmi i capelli propecia e isotrenina (retin-a) per via topica e un ciclo all'anno per via orale (roaccutane9 dato che numerosi studi, dimostrano l'efficacia di questo principio sulla cuio capelluto e io l'ho provato ed e' vero , anche se non si e' ancora capito esattamente le dinamiche che spiegano il fenomeno,